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Targeting FGF19/FGFR4 Pathway: A Novel Therapeutic Strategy for Hepatocellular Carcinoma

by Dimitra Repana 1 and Paul Ross 1,2,*
Department of Medical Oncology, Guy’s and St. Thomas’ NHS Foundation Trust, SE1 9RT London, UK
Department of Oncology, King’s College Hospital, SE19 1RT London, UK
Author to whom correspondence should be addressed.
Academic Editor: Stephen L. Chan
Diseases 2015, 3(4), 294-305;
Received: 20 August 2015 / Revised: 28 September 2015 / Accepted: 20 October 2015 / Published: 28 October 2015
(This article belongs to the Special Issue Targeted Therapy of Hepatocellular Carcinoma: Present and Future)
Hepatocellular carcinoma (HCC) is a lethal cancer with limited systemic therapeutic options. Liver carcinogenesis is a complex procedure and various pathways have been found to be deregulated which are potential targets for novel treatments. Aberrant signalling through FGF19 and its receptor FGFR4 seems to be the oncogenic driver for a subset of HCCs and is associated with poor prognosis. Inhibition of the pathway in preclinical models has shown antitumour activity and has triggered further evaluation of this strategy to in vivo models. This review aims to describe the role of the FGF19/FGFR4 pathway in hepatocellular carcinoma and its role as a potential predictive biomarker for novel targeted agents against FGF19/FGFR4 signalling. View Full-Text
Keywords: hepatocellular carcinoma; FGF19; FGFR4; β-Klotho hepatocellular carcinoma; FGF19; FGFR4; β-Klotho
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Repana, D.; Ross, P. Targeting FGF19/FGFR4 Pathway: A Novel Therapeutic Strategy for Hepatocellular Carcinoma. Diseases 2015, 3, 294-305.

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