Collateral Damage in the Placenta during Viral Infection in Pregnancy: A Possible Mechanism for Vertical Transmission and an Adverse Pregnancy Outcome

Cruz-Holguín, Victor Javier; González-García, Luis Didier; Velázquez-Cervantes, Manuel Adrián; Arévalo-Romero, Haruki; De Jesús-González, Luis Adrián; Helguera-Repetto, Addy Cecilia; León-Reyes, Guadalupe; Salazar, Ma. Isabel; Cedillo-Barrón, Leticia; León-Juárez, Moisés

doi:10.3390/diseases12030059

Open AccessReview

Collateral Damage in the Placenta during Viral Infection in Pregnancy: A Possible Mechanism for Vertical Transmission and an Adverse Pregnancy Outcome

by

Victor Javier Cruz-Holguín

^1,2,†,

Luis Didier González-García

^1,2,3,†,

Manuel Adrián Velázquez-Cervantes

¹,

Haruki Arévalo-Romero

⁴,

Luis Adrián De Jesús-González

⁵

,

Addy Cecilia Helguera-Repetto

⁶,

Guadalupe León-Reyes

⁷,

Ma. Isabel Salazar

^3,8,

Leticia Cedillo-Barrón

²

and

Moisés León-Juárez

^1,*

¹

Laboratorio de Virologia Perinatal y Diseño Molecular de Antigenos y Biomarcadores, Departamento de Inmunobioquimica, Instituto Nacional de Perinatología, Mexico City 11000, Mexico

²

Departamento de Biomedicina Molecular, Centro de Investigación y Estudios Avanzados del IPN (CINVESTAV), Mexico City 07360, Mexico

³

Posgrado de Inmunología, Escuela Nacional de Ciencias Biologócas (ENCB), Instituto Politecnico Naciona, Mexico City 11350, Mexico

⁴

Laboratorio de Inmunologia y Microbiologia Molecular, Division Academica Multidisciplinaria de Jalpa de Méndez, Jalpa de Mendez 86205, Mexico

⁵

Unidad de Investigación Biomédica de Zacatecas, Instituto Mexicano del Seguro Social, Zacatecas 98000, Mexico

⁶

Departamento de Inmunobioquimica, Instituto Nacional de Perinatología, Mexico City 11000, Mexico

⁷

Laboratorio de Nutrigenética y Nutrigenómica, Instituto Nacional de Medicina Genómica (INMEGEN), Mexico City 14610, Mexico

⁸

Laboratorio Nacional de Vacunología y Virus Tropicales (LNVyVT), Escuela Nacional de Ciencias Biologócas (ENCB), Instituto Politecnico Naciona, Mexico City 11350, Mexico

^*

Author to whom correspondence should be addressed.

^†

These authors contributed equally to this work.

Diseases 2024, 12(3), 59; https://doi.org/10.3390/diseases12030059

Submission received: 30 January 2024 / Revised: 3 March 2024 / Accepted: 6 March 2024 / Published: 20 March 2024

(This article belongs to the Special Issue Recent Advances in Diseases: Featured Reviews)

Download

Browse Figures

Review Reports Versions Notes

Abstract

In mammals, the placenta is a connection between a mother and a new developing organism. This tissue has a protective function against some microorganisms, transports nutrients, and exchanges gases and excretory substances between the mother and the fetus. Placental tissue is mainly composed of chorionic villi functional units called trophoblasts (cytotrophoblasts, the syncytiotrophoblast, and extravillous trophoblasts). However, some viruses have developed mechanisms that help them invade the placenta, causing various conditions such as necrosis, poor perfusion, and membrane rupture which, in turn, can impact the development of the fetus and put the mother’s health at risk. In this study, we collected the most relevant information about viral infection during pregnancy which can affect both the mother and the fetus, leading to an increase in the probability of vertical transmission. Knowing these mechanisms could be relevant for new research in the maternal–fetal context and may provide options for new therapeutic targets and biomarkers in fetal prognosis.

Keywords: virus; placenta; trophoblast; pregnancy; maternal–fetal interface

Share and Cite

MDPI and ACS Style

Cruz-Holguín, V.J.; González-García, L.D.; Velázquez-Cervantes, M.A.; Arévalo-Romero, H.; De Jesús-González, L.A.; Helguera-Repetto, A.C.; León-Reyes, G.; Salazar, M.I.; Cedillo-Barrón, L.; León-Juárez, M. Collateral Damage in the Placenta during Viral Infection in Pregnancy: A Possible Mechanism for Vertical Transmission and an Adverse Pregnancy Outcome. Diseases 2024, 12, 59. https://doi.org/10.3390/diseases12030059

AMA Style

Cruz-Holguín VJ, González-García LD, Velázquez-Cervantes MA, Arévalo-Romero H, De Jesús-González LA, Helguera-Repetto AC, León-Reyes G, Salazar MI, Cedillo-Barrón L, León-Juárez M. Collateral Damage in the Placenta during Viral Infection in Pregnancy: A Possible Mechanism for Vertical Transmission and an Adverse Pregnancy Outcome. Diseases. 2024; 12(3):59. https://doi.org/10.3390/diseases12030059

Chicago/Turabian Style

Cruz-Holguín, Victor Javier, Luis Didier González-García, Manuel Adrián Velázquez-Cervantes, Haruki Arévalo-Romero, Luis Adrián De Jesús-González, Addy Cecilia Helguera-Repetto, Guadalupe León-Reyes, Ma. Isabel Salazar, Leticia Cedillo-Barrón, and Moisés León-Juárez. 2024. "Collateral Damage in the Placenta during Viral Infection in Pregnancy: A Possible Mechanism for Vertical Transmission and an Adverse Pregnancy Outcome" Diseases 12, no. 3: 59. https://doi.org/10.3390/diseases12030059

APA Style

Cruz-Holguín, V. J., González-García, L. D., Velázquez-Cervantes, M. A., Arévalo-Romero, H., De Jesús-González, L. A., Helguera-Repetto, A. C., León-Reyes, G., Salazar, M. I., Cedillo-Barrón, L., & León-Juárez, M. (2024). Collateral Damage in the Placenta during Viral Infection in Pregnancy: A Possible Mechanism for Vertical Transmission and an Adverse Pregnancy Outcome. Diseases, 12(3), 59. https://doi.org/10.3390/diseases12030059

Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details here.

Article Menu

Collateral Damage in the Placenta during Viral Infection in Pregnancy: A Possible Mechanism for Vertical Transmission and an Adverse Pregnancy Outcome

Abstract

Share and Cite

Article Metrics

Article Access Statistics

Further Information

Guidelines

MDPI Initiatives

Follow MDPI