Next Article in Journal
The Assessment of SF-36 Survey for Quality-of-Life Measurement after Radical Cystectomy for Muscle-Invasive Bladder Cancer: A Systematic Review
Previous Article in Journal
Association between Dietary Practice and Gait Speed in Community-Dwelling Older Adults with Overweight and Obesity: A Cross-Sectional Study
 
 
Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
Journals
Diseases
Volume 12
Issue 3
10.3390/diseases12030055
diseases-logo
Submit to this Journal Review for this Journal Propose a Special Issue
► Article Menu

Article Menu

share Share announcement Help format_quote Cite question_answer Discuss in SciProfiles
first_page
settings
Order Article Reprints
Font Type:
Arial Georgia Verdana
Font Size:
Aa Aa Aa
Line Spacing:
Column Width:
Background:
Article

Serum Pro-Inflammatory Cytokines and Leptin as Potential Biomarkers for Treatment Response and Toxicity in Locally Advanced Squamous Cell Carcinoma of the Head and Neck

by
Amani A. Alrehaili
1,*,
Amal F. Gharib
1,
Maha M. Bakhuraysah
1,
Afaf Alharthi
1,
Ohud Alsalmi
1,
Fouzeyyah Ali Alsaeedi
1,
Reem Ali Alhakami
1,
Kamilah Ali Alasmari
1,
Nuha Mohammed
2 and
Wael H. Elsawy
3
1
Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, Taif University, P.O. Box 11099, Taif 21944, Saudi Arabia
2
Laboratory and Blood Bank, King Faisal Medical Complex, Ministry of Health, Taif 26524, Saudi Arabia
3
Department of Clinical Oncology, Faculty of Medicine, Zagazig University, Zagazig 7120001, Egypt
*
Author to whom correspondence should be addressed.
Diseases 2024, 12(3), 55; https://doi.org/10.3390/diseases12030055
Submission received: 6 January 2024 / Revised: 6 March 2024 / Accepted: 7 March 2024 / Published: 11 March 2024
Browse Figure
Versions Notes

Abstract

Squamous cell carcinoma of the head and neck (HNSCC) is a globally prevalent form of cancer with significant morbidity and mortality rates. The present study examines the relationship of serum pro-inflammatory cytokines and leptin levels with the effectiveness of therapy in individuals with HNSCC and their potential role as biomarkers for treatment response and toxicity. Induction chemotherapy and concomitant chemoradiotherapy were evaluated for efficacy and safety in 52 individuals with HNSCC. Both response and toxicity were evaluated, and serum levels of pro-inflammatory cytokines Interlukin-1 beta (IL-1β), Interlukin-2 (IL-2), Interlukin-6 (IL-6), and Tumor Necrosis Factor-Alpha (TNF-α) and leptin were measured using enzyme-linked immunoassay before and after treatment. Before treatment, these measurements were made in comparison with a control group with 50 healthy people. The results showed that serum cytokines and leptin levels varied depending on the response to treatment, with patients who had a complete or partial response (PR) showing significant decreases in IL-1 β, IL-6, and TNF-α levels and significant increases in IL-2 and leptin levels after treatment, with an improvement in cachexia. These results imply that variations in serum pro-inflammatory cytokines and leptin levels are likely related to the therapeutic effectiveness in HNSCC and may act as biomarkers for treatment response.
Keywords: head and neck squamous cell carcinoma; cytokines; treatment response; biomarkers head and neck squamous cell carcinoma; cytokines; treatment response; biomarkers

Share and Cite

MDPI and ACS Style

Alrehaili, A.A.; Gharib, A.F.; Bakhuraysah, M.M.; Alharthi, A.; Alsalmi, O.; Alsaeedi, F.A.; Alhakami, R.A.; Alasmari, K.A.; Mohammed, N.; Elsawy, W.H. Serum Pro-Inflammatory Cytokines and Leptin as Potential Biomarkers for Treatment Response and Toxicity in Locally Advanced Squamous Cell Carcinoma of the Head and Neck. Diseases 2024, 12, 55. https://doi.org/10.3390/diseases12030055

AMA Style

Alrehaili AA, Gharib AF, Bakhuraysah MM, Alharthi A, Alsalmi O, Alsaeedi FA, Alhakami RA, Alasmari KA, Mohammed N, Elsawy WH. Serum Pro-Inflammatory Cytokines and Leptin as Potential Biomarkers for Treatment Response and Toxicity in Locally Advanced Squamous Cell Carcinoma of the Head and Neck. Diseases. 2024; 12(3):55. https://doi.org/10.3390/diseases12030055

Chicago/Turabian Style

Alrehaili, Amani A., Amal F. Gharib, Maha M. Bakhuraysah, Afaf Alharthi, Ohud Alsalmi, Fouzeyyah Ali Alsaeedi, Reem Ali Alhakami, Kamilah Ali Alasmari, Nuha Mohammed, and Wael H. Elsawy. 2024. "Serum Pro-Inflammatory Cytokines and Leptin as Potential Biomarkers for Treatment Response and Toxicity in Locally Advanced Squamous Cell Carcinoma of the Head and Neck" Diseases 12, no. 3: 55. https://doi.org/10.3390/diseases12030055

APA Style

Alrehaili, A. A., Gharib, A. F., Bakhuraysah, M. M., Alharthi, A., Alsalmi, O., Alsaeedi, F. A., Alhakami, R. A., Alasmari, K. A., Mohammed, N., & Elsawy, W. H. (2024). Serum Pro-Inflammatory Cytokines and Leptin as Potential Biomarkers for Treatment Response and Toxicity in Locally Advanced Squamous Cell Carcinoma of the Head and Neck. Diseases, 12(3), 55. https://doi.org/10.3390/diseases12030055

Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details here.

Article Metrics

Back to TopTop