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Inflammatory Bowel Disease: An Indication to Screen for Thrombophilia?

Division of Hematology and Oncology, Department of Internal Medicine, Naef K. Basile Cancer Institute, American University of Beirut Medical Center, P.O. Box 11-0236, Riad El Solh, Beirut 1107 2020, Lebanon
Department of Gastroenterology and Hepatology, Mayo Clinic, Jacksonville, FL 32224, USA
Author to whom correspondence should be addressed.
Academic Editors: Roberto De Giorgio and Gaetano Santulli
Diseases 2022, 10(1), 14;
Received: 31 December 2021 / Revised: 17 February 2022 / Accepted: 18 February 2022 / Published: 23 February 2022
(This article belongs to the Section Gastroenterology)
Inflammatory bowel diseases (IBD) are systemic conditions characterized by multiple intestinal and extra-intestinal manifestations related to the associated chronic inflammatory state. Among their diverse extra-intestinal complications, venous thromboembolism (VTE) remains one of the most under recognized causes of morbidity and mortality in these patients, highlighting the need for a better understanding of the underlying mechanism of hypercoagulability, in addition to the role of acquired and inherited risk factors that further increase the risk of thrombosis with its impact on patients’ outcomes. We hereby present a review of the data regarding thrombosis in the setting of IBD, elucidating the possible role for screening in this high-risk category of patients and specifically in areas where inherited thrombophilia is expected to be highly prevalent, reporting two patients with IBD, one who developed a cerebrovascular event and another one who had recurrent VTE events; nevertheless, both of them had inherited thrombophilic mutations. The identification of specific genetic abnormalities in those patients reintroduces the controversy related to the need to screen a specific category of patients with IBD for hereditary thrombophilia, especially in regions characterized by a higher prevalence of such thrombophilic alterations. View Full-Text
Keywords: inflammatory bowel disease; thrombosis; hereditary thrombophilia inflammatory bowel disease; thrombosis; hereditary thrombophilia
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MDPI and ACS Style

Moukalled, N.M.; Hashash, J.G.; Taher, A.T. Inflammatory Bowel Disease: An Indication to Screen for Thrombophilia? Diseases 2022, 10, 14.

AMA Style

Moukalled NM, Hashash JG, Taher AT. Inflammatory Bowel Disease: An Indication to Screen for Thrombophilia? Diseases. 2022; 10(1):14.

Chicago/Turabian Style

Moukalled, Nour M., Jana G. Hashash, and Ali T. Taher. 2022. "Inflammatory Bowel Disease: An Indication to Screen for Thrombophilia?" Diseases 10, no. 1: 14.

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