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Article

Molecular Docking, Tyrosinase, Collagenase, and Elastase Inhibition Activities of Argan By-Products

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Laboratory of Biotechnologies and Valorization of Natural Resources, Faculty of Sciences, University Ibn Zohr-Agadir, Agadir 80000, Morocco
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Research Team on Biological Engineering, Agrifood and Aquaculture, Polydisciplinary Faculty of Larache, Abdelmalek Essaadi University, Tetouan 95000, Morocco
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Center for Studies and Research of Medicinal Plants (NEPLAME), Federal University of Vale do São Francisco, Petrolina 56304-205, Brazil
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LEPABE—Laboratory for Process Engineering, Environment, Biotechnology and Energy, Faculty of Engineering, University of Porto, Rua Dr. Roberto Frias, 4200-465 Porto, Portugal
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ALiCE—Associate Laboratory in Chemical Engineering, Faculty of Engineering, University of Porto, Rua Dr. Roberto Frias, 4200-465 Porto, Portugal
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Author to whom correspondence should be addressed.
Academic Editor: Enzo Berardesca
Cosmetics 2022, 9(1), 24; https://doi.org/10.3390/cosmetics9010024
Received: 28 January 2022 / Revised: 9 February 2022 / Accepted: 11 February 2022 / Published: 14 February 2022
(This article belongs to the Special Issue Feature Papers in Cosmetics in 2022)
The argan tree (Argania spinosa (L.) Skeels) is one of the most important floristic resources in Morocco. This Moroccan endemic tree is known for its numerous therapeutic and medicinal uses. In addition to some medicinal and cosmetic uses, argan fruit pulp and press cake are traditionally used by the Berber population for heating and feeding livestock. Molecular docking is an in silico approach that predicts the interaction between a ligand and a protein. This approach is mainly used in chemistry and pharmacology of natural products as a prediction tool with the purpose of selecting plant extracts or fractions for in vitro tests. The aim of this research is to study the evaluation of potential tyrosinase, collagenase, and elastase inhibitory activities of argan fruit press-cake and pulp extracts. Extracts were evaluated for their total phenolic content (TPC), and the major polyphenols of both press-cake and pulp extracts were submitted to molecular docking in order to determine the mechanisms of action of these compounds. Obtained results revealed that fruit pulp had the strongest dermocosmetic activities, as well as the highest TPC, with values above 55 mg gallic-acid equivalent per gram of dry matter (mgeq AG/gDM). Moreover, those results were positively correlated with the docking findings, suggesting that the pulp lead compounds have higher affinity with tyrosinase, collagenase, and elastase action sites. The results here presented are very promising and open new perspectives for the exploitation of argan-tree by-products as cosmetic agents towards the development of new anti-aging products. View Full-Text
Keywords: argan tree by-products; press cake; fruit pulp; natural dermocosmetics; molecular docking; inhibition; tyrosinase; collagenase; elastase argan tree by-products; press cake; fruit pulp; natural dermocosmetics; molecular docking; inhibition; tyrosinase; collagenase; elastase
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MDPI and ACS Style

Mechqoq, H.; Hourfane, S.; El Yaagoubi, M.; El Hamdaoui, A.; da Silva Almeida, J.R.G.; Rocha, J.M.; El Aouad, N. Molecular Docking, Tyrosinase, Collagenase, and Elastase Inhibition Activities of Argan By-Products. Cosmetics 2022, 9, 24. https://doi.org/10.3390/cosmetics9010024

AMA Style

Mechqoq H, Hourfane S, El Yaagoubi M, El Hamdaoui A, da Silva Almeida JRG, Rocha JM, El Aouad N. Molecular Docking, Tyrosinase, Collagenase, and Elastase Inhibition Activities of Argan By-Products. Cosmetics. 2022; 9(1):24. https://doi.org/10.3390/cosmetics9010024

Chicago/Turabian Style

Mechqoq, Hicham, Sohaib Hourfane, Mohamed El Yaagoubi, Abdallah El Hamdaoui, Jackson Roberto Guedes da Silva Almeida, Joao Miguel Rocha, and Noureddine El Aouad. 2022. "Molecular Docking, Tyrosinase, Collagenase, and Elastase Inhibition Activities of Argan By-Products" Cosmetics 9, no. 1: 24. https://doi.org/10.3390/cosmetics9010024

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