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Article

Skin Brightening Efficacy of Exosomes Derived from Human Adipose Tissue-Derived Stem/Stromal Cells: A Prospective, Split-Face, Randomized Placebo-Controlled Study

1
ExoCoBio Exosome Institute (EEI), ExoCoBio Inc., Seoul 08594, Korea
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Department of Plastic Surgery, Plastic Surgical Associates of Fort Collins, P.C., Fort Collins, CO 80525, USA
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RJ Clinical Institute, Mission Viejo, CA 92691, USA
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School of Chemical and Biological Engineering, Seoul National University, Seoul 08826, Korea
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Oaro Dermatology Institute, Seoul 05269, Korea
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Department of Dermatology, Dongtan Sacred Heart Hospital, Hallym University College of Medicine, Hwaseong 18450, Gyeonggi-do, Korea
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Guam Dermatology Institute, Tamuning, GU 96913, USA
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Department of Dermatology, College of Medicine, Dankook University, Cheonan 31116, Korea
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Department of Dermatology, College of Medicine, Chung-Ang University, Seoul 156755, Korea
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Biosensor Laboratories, Inc., Seoul 08826, Korea
*
Authors to whom correspondence should be addressed.
Cosmetics 2020, 7(4), 90; https://doi.org/10.3390/cosmetics7040090
Received: 9 October 2020 / Revised: 11 November 2020 / Accepted: 11 November 2020 / Published: 13 November 2020
(This article belongs to the Special Issue Feature Papers in Cosmetics in 2020)
Studies have shown that stem cells and their derivatives, including conditioned media (CM), have inhibitory effects on skin pigmentation. However, evidence supporting the skin brightening effect of exosomes derived from stem cells is lacking. We studied the antipigmentation effect in vitro and skin brightening efficacy in vivo of exosomes derived from human adipose tissue-derived mesenchymal stem/stromal cells (ASC-exosomes). Exosomes were isolated from the CM of ASCs using the tangential flow filtration method. ASC-exosomes reduced intracellular melanin levels in B16F10 melanoma cells regardless of the presence of the α-melanocyte-stimulating hormone (α-MSH). The skin brightening efficacy of a cosmetic formulation containing ASC-exosomes was assessed in human volunteers with hyperpigmentation in a prospective, split-face, double-blind, randomized placebo-controlled study. The ASC-exosome-containing formulation statistically decreased the melanin contents compared to the placebo control. However, the melanin-reduction activity was limited and diminished along with time. A further improvement in efficient transdermal delivery of ASC-exosomes will be helpful for more profound efficacy. In summary, these results suggest that ASC-exosomes can be used as a cosmeceutical for skin brightening. View Full-Text
Keywords: adipose tissue-derived stem/stromal cells (ASCs); ASC-exosomes; hyperpigmentation; melanocyte; skin brightening adipose tissue-derived stem/stromal cells (ASCs); ASC-exosomes; hyperpigmentation; melanocyte; skin brightening
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MDPI and ACS Style

Cho, B.S.; Lee, J.; Won, Y.; Duncan, D.I.; Jin, R.C.; Lee, J.; Kwon, H.H.; Park, G.-H.; Yang, S.H.; Park, B.C.; Park, K.Y.; Youn, J.; Chae, J.; Jung, M.; Yi, Y.W. Skin Brightening Efficacy of Exosomes Derived from Human Adipose Tissue-Derived Stem/Stromal Cells: A Prospective, Split-Face, Randomized Placebo-Controlled Study. Cosmetics 2020, 7, 90. https://doi.org/10.3390/cosmetics7040090

AMA Style

Cho BS, Lee J, Won Y, Duncan DI, Jin RC, Lee J, Kwon HH, Park G-H, Yang SH, Park BC, Park KY, Youn J, Chae J, Jung M, Yi YW. Skin Brightening Efficacy of Exosomes Derived from Human Adipose Tissue-Derived Stem/Stromal Cells: A Prospective, Split-Face, Randomized Placebo-Controlled Study. Cosmetics. 2020; 7(4):90. https://doi.org/10.3390/cosmetics7040090

Chicago/Turabian Style

Cho, Byong S., Jinah Lee, Yujin Won, Diane I. Duncan, Richard C. Jin, Joon Lee, Hyuck H. Kwon, Gyeong-Hun Park, Steven H. Yang, Byung C. Park, Kui Y. Park, Jinkwon Youn, Junsoo Chae, Minwoong Jung, and Yong W. Yi 2020. "Skin Brightening Efficacy of Exosomes Derived from Human Adipose Tissue-Derived Stem/Stromal Cells: A Prospective, Split-Face, Randomized Placebo-Controlled Study" Cosmetics 7, no. 4: 90. https://doi.org/10.3390/cosmetics7040090

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