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Cosmetics 2018, 5(3), 44; https://doi.org/10.3390/cosmetics5030044

A Green and Rapid Analytical Method for the Determination of Hydroxyethoxyphenyl Butanone in Cosmetic Products by Liquid Chromatography

Department of Analytical Chemistry, Faculty of Chemistry, University of Valencia, Doctor Moliner St. 50, 46100 Valencia, Spain
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Received: 12 June 2018 / Revised: 13 July 2018 / Accepted: 13 July 2018 / Published: 16 July 2018
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Abstract

An analytical method for the determination of hydroxyethoxyphenyl butanone, which is used as an alternative preservative in cosmetic products, has been developed and validated for the first time. The method is based on a simple ultrasound-assisted lixiviation of the analyte from the cosmetic matrix followed by liquid chromatography with UV spectrophotometric detection. Under optimized conditions, the method limit of detection and limit of quantification values were 30 and 90 µg·g−1, respectively. The method was validated with good recovery values (86–103%) and precision values (RSD 0.2–4.7%). Finally, the proposed analytical method was successfully applied to 7 commercially available cosmetic samples including both lipophilic and hydrophilic matrices, such as moisturizing cream, sunscreen, shampoo, liquid hand soap, and make-up. Additionally, a laboratory-made cosmetic cream containing the target analyte was prepared and analyzed. The good analytical figures of merit of the proposed method, in addition to its environmentally-friendly characteristics, demonstrate its usefulness to perform the quality control of cosmetic products to ensure the safety of consumers. View Full-Text
Keywords: alternative preservatives; hydroxyethoxyphenyl butanone; cosmetic products; liquid chromatography; ultraviolet-visible spectrophotometry alternative preservatives; hydroxyethoxyphenyl butanone; cosmetic products; liquid chromatography; ultraviolet-visible spectrophotometry
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Miralles, P.; Benedé, J.L.; Mata-Martín, A.; Chisvert, A.; Salvador, A. A Green and Rapid Analytical Method for the Determination of Hydroxyethoxyphenyl Butanone in Cosmetic Products by Liquid Chromatography. Cosmetics 2018, 5, 44.

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