1. Introduction
2. Materials and Methods
2.1. Materials
2.1.1. Plant Material
2.1.2. Chemicals
2.2. Method
2.2.1. Extraction of the Plant Material
2.2.2. Determination of Antioxidant Capacity
2.2.3. Formulation Development
2.2.4. Emulsion Stability Test
2.2.5. Evaluation of the Emulsion on Human Skin
2.2.6. Patch Test
2.2.7. Mathematical Analysis
2.2.8. Statistical Analysis
3. Results and Discussion
3.1. Stability Tests for Base and Formulation
3.2. Dermatological Tests
3.2.1. Melanin
3.2.2. Erythema
3.2.3. Skin Moisture Content
3.2.4. Skin Sebum Content
3.2.5. Skin Elasticity
4. Conclusions
Acknowledgments
Author Contributions
Conflicts of Interest
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Phase | Placebo Cream | Cream with Extract |
---|---|---|
Oily Phase | Liquid paraffin—16% | Liquid paraffin—16% |
ABIL EM 90—2.5% | ABIL_ EM 90—2.5% | |
Aqueous Phase | Distilled water (q.s)—100% | Plant extract—4% (conc.) |
Distilled water (q.s)—100% |
Observed Parameters | Fresh | At 8 °C | At 25 °C | At 40 °C | 40 °C with 75% RH | At 50 °C | ||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
After 28 Days | After 28 Days | After 28 Days | After 28 Days | After 28 Days | ||||||||
B | F | B | F | B | F | B | F | B | F | B | F | |
Color | W | OW | W | OW | W | OW | W | OW | W | OW | W | OW |
Liquefaction | NA | NA | − | − | − | − | − | − | + | − | + | + |
Phase separation | NA | NA | − | − | − | − | − | − | + | − | + | + |
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