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Cosmetics
Volume 13
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10.3390/cosmetics13010028
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This is an early access version, the complete PDF, HTML, and XML versions will be available soon.
Article

Evaluation of Cacumen Platycladi Extract for Hair Loss Prevention: Mechanisms, Efficacy, and Clinical Application

by
Xue-Dong Bai
1,
Yu-Chen Liu
1,
Hong-Yun Zhao
1,
Yi-Zhou Luo
1,
Li-Jun Xu
1,2,* and
Feng Luo
1,*
1
R&D Center of Shanghai Huiwen Biotech Co., Ltd., No. 879 Ziping Road, Shanghai 201318, China
2
School of Resources and Environmental Engineering, Shanghai Polytechnic University, No. 2360 Jinhai Road, Shanghai 201209, China
*
Authors to whom correspondence should be addressed.
Cosmetics 2026, 13(1), 28; https://doi.org/10.3390/cosmetics13010028
Submission received: 24 November 2025 / Revised: 25 December 2025 / Accepted: 8 January 2026 / Published: 26 January 2026
(This article belongs to the Section Cosmetic Dermatology)
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Abstract

Hair loss is a prevalent condition with various causes, and effective treatments are in high demand. Cacumen Platycladi (Platycladus orientalis leaves), a traditional Chinese medicine, has been historically used to prevent hair loss. This study aimed to evaluate the efficacy and mechanisms of Cacumen Platycladi extract (CPE) in preventing hair loss. Using a gradient extraction method with 1,3-butanediol, ethanol, and water, bioactive compounds like quercitrin, myricetin, and myricitrin were enriched and identified via Liquid Chromatography–Mass Spectrometry (LC-MS). The results showed that CPE inhibited 5α-reductase activity, enhanced the antioxidant capacity of human dermal papilla cells (HDPCs), and upregulated the phosphoinositide 3-kinase (PI3K)/protein kinase B (Akt)/mammalian target of rapamycin (mTOR) pathway to promote vascular endothelial growth factor (VEGF) and collagen type XVII (COL17) expression. A 12-week clinical trial demonstrated that CPE significantly reduced hair loss and increased local hair density compared to placebo, with no adverse effects. These findings support the potential of CPE as a safe and effective natural alternative for hair loss prevention.
Keywords: Cacumen Platycladi; hair loss; HDPCs; clinical trial Cacumen Platycladi; hair loss; HDPCs; clinical trial
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MDPI and ACS Style

Bai, X.-D.; Liu, Y.-C.; Zhao, H.-Y.; Luo, Y.-Z.; Xu, L.-J.; Luo, F. Evaluation of Cacumen Platycladi Extract for Hair Loss Prevention: Mechanisms, Efficacy, and Clinical Application. Cosmetics 2026, 13, 28. https://doi.org/10.3390/cosmetics13010028

AMA Style

Bai X-D, Liu Y-C, Zhao H-Y, Luo Y-Z, Xu L-J, Luo F. Evaluation of Cacumen Platycladi Extract for Hair Loss Prevention: Mechanisms, Efficacy, and Clinical Application. Cosmetics. 2026; 13(1):28. https://doi.org/10.3390/cosmetics13010028

Chicago/Turabian Style

Bai, Xue-Dong, Yu-Chen Liu, Hong-Yun Zhao, Yi-Zhou Luo, Li-Jun Xu, and Feng Luo. 2026. "Evaluation of Cacumen Platycladi Extract for Hair Loss Prevention: Mechanisms, Efficacy, and Clinical Application" Cosmetics 13, no. 1: 28. https://doi.org/10.3390/cosmetics13010028

APA Style

Bai, X.-D., Liu, Y.-C., Zhao, H.-Y., Luo, Y.-Z., Xu, L.-J., & Luo, F. (2026). Evaluation of Cacumen Platycladi Extract for Hair Loss Prevention: Mechanisms, Efficacy, and Clinical Application. Cosmetics, 13(1), 28. https://doi.org/10.3390/cosmetics13010028

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