A Case Series Report on Superficial Application of Polydensified Cohesive Matrix Hyaluronic Acid Through Biopsies

The skin comprises three main layers: epidermis, dermis, and hypodermis. The dermis is formed by connective tissue with an extracellular matrix composed of glycosaminoglycans and collagen fibers, providing skin resistance. During aging, the loss of the skin’s biomechanical properties results in sagging. Exogenous hyaluronic acid is highly used as a filler. However, few studies using biopsies have demonstrated its action as a dermal remodeler and collagen stimulator in superficial applications and using polidensified cohesive gel. Methods: Skin tissues obtained from biopsies in the patient’s arms were evaluated for histological, immunohistochemical, and biochemical analyses, in addition to clinical assessments by skin ultrasound. Biopsies were performed at time zero, three, and six months after intradermal injection of hyaluronic acid with a polydensified cohesive matrix in four women of different age groups. Results: The individual results showed hyaluronic acid synthesis, an increase in type I and III collagen, and a thickening of the dermal layer after the treatment. Conclusion: In four thirty-five to sixty-year-old patients, we observed the effectiveness of using polydensified cohesive matrix hyaluronic acid as a collagen stimulator, thickening the dermis and stimulating endogenous hyaluronic acid synthesis. This study highlights the importance of individual analysis of the variables studied.