Holobiont Rebalancing by a Natural Gentian Extract on a Skin Dehydration Model
Abstract
:1. Introduction
2. Materials and Methods
2.1. Fermented Extract Production (In-House Experiments)
2.2. In Vitro Evaluation of Biological Activity (In-House Experiments)
2.2.1. Hyaluronic Acid Dosage
2.2.2. Epifluorescence Microscopy for CD44 and Lipids Quantification
2.3. In Vivo Evaluation of Biological Activity
2.3.1. Skin Benefit Evaluation
2.3.2. Metaproteomic Analysis
2.4. Statistical Analyses
3. Results
3.1. GFE Improves Hyaluronic Acid Pathway In Vitro
3.2. GFE Increases Lipid Synthesis In Vitro
3.3. GFE Stimulates Hydration on Dry Skins
3.4. GFE Protects or Restores the Skin Surface Lipids According to Skin Condition
3.5. GFE Restores in Older Dehydrated Skin the Holobiotic Characteristics of Younger Skin and Stimulates Beneficial Bacteria Species
4. Discussion
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Roux, L.N.; Dreux-Zigha, A.; Rey, C.; Boutot, C.; Laurent, Y.; Beytur, S.; Metton, I.; Abraham, J.-D.; Berthon, J.-Y. Holobiont Rebalancing by a Natural Gentian Extract on a Skin Dehydration Model. Cosmetics 2024, 11, 132. https://doi.org/10.3390/cosmetics11040132
Roux LN, Dreux-Zigha A, Rey C, Boutot C, Laurent Y, Beytur S, Metton I, Abraham J-D, Berthon J-Y. Holobiont Rebalancing by a Natural Gentian Extract on a Skin Dehydration Model. Cosmetics. 2024; 11(4):132. https://doi.org/10.3390/cosmetics11040132
Chicago/Turabian StyleRoux, Lauriane N., Assia Dreux-Zigha, Célia Rey, Carine Boutot, Yoan Laurent, Sercan Beytur, Isabelle Metton, Jean-Daniel Abraham, and Jean-Yves Berthon. 2024. "Holobiont Rebalancing by a Natural Gentian Extract on a Skin Dehydration Model" Cosmetics 11, no. 4: 132. https://doi.org/10.3390/cosmetics11040132