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Article

Evaluation of the Activity and Tolerability of a Cosmetic Treatment for the Periocular Area on the Aging Face: Controlled Clinical and Instrumental Evaluation vs. Placebo

1
DermIng S.r.l. Clinical Research Institute, Viale Cesare Battisti 38, 20900 Monza, Italy
2
Sinerga SpA, Via della Pacciarna 67, 21050 Gorla Maggiore, Italy
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Cosmetics 2014, 1(2), 105-116; https://doi.org/10.3390/cosmetics1020105
Received: 7 February 2014 / Revised: 13 May 2014 / Accepted: 13 May 2014 / Published: 21 May 2014
(This article belongs to the Special Issue Selected Papers from ISBS/SICC 1st Joint International Congress)
The aim of this study was to evaluate clinically and by non invasive instrumental evaluations the efficacy and tolerability of a cosmetic treatment containing an innovative active ingredient, ethyl ximenynate, in the prevention of dark circles under the eyes and blemishes of skin aging on the eye profile. Evaluations were performed at baseline and after 2 and 4 weeks of treatment on 22 volunteers; the study was planned as a double blind half-face trial. Data showed a trend towards a lifting of the eyelid skin; all investigator scores (eye puffiness, skin smoothness, roughness and dryness) decreased. In addition, profilometric results confirmed the anti-wrinkles efficacy of the active product and its lifting action, while those related to spectrophotometry underlined the decongestant effect on dark circles that appeared, at the end of the study, to be less marked. The improvement of skin microcirculation and capillary resistance and vascular tone in the eye area underlines a general mitigation of all relevant skin imperfections and blemishes of skin aging on the eye profile. The active ingredient was shown to be effective for the cosmetic treatment of the periocular area. View Full-Text
Keywords: circles under the eye; periocular wrinkles; eye profile; ethyl ximenynate circles under the eye; periocular wrinkles; eye profile; ethyl ximenynate
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MDPI and ACS Style

Sparavigna, A.; Tenconi, B.; De Ponti, I.; Guglielmini, G. Evaluation of the Activity and Tolerability of a Cosmetic Treatment for the Periocular Area on the Aging Face: Controlled Clinical and Instrumental Evaluation vs. Placebo. Cosmetics 2014, 1, 105-116. https://doi.org/10.3390/cosmetics1020105

AMA Style

Sparavigna A, Tenconi B, De Ponti I, Guglielmini G. Evaluation of the Activity and Tolerability of a Cosmetic Treatment for the Periocular Area on the Aging Face: Controlled Clinical and Instrumental Evaluation vs. Placebo. Cosmetics. 2014; 1(2):105-116. https://doi.org/10.3390/cosmetics1020105

Chicago/Turabian Style

Sparavigna, Adele, Beatrice Tenconi, Ileana De Ponti, and Giancarlo Guglielmini. 2014. "Evaluation of the Activity and Tolerability of a Cosmetic Treatment for the Periocular Area on the Aging Face: Controlled Clinical and Instrumental Evaluation vs. Placebo" Cosmetics 1, no. 2: 105-116. https://doi.org/10.3390/cosmetics1020105

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