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A Cell Biological Perspective on Past, Present and Future Investigations of the Spindle Assembly Checkpoint

Cell & Developmental Biology, University of Michigan Medical School, Ann Arbor, MI 48109, USA
Academic Editor: J. Richard McIntosh
Biology 2016, 5(4), 44; https://doi.org/10.3390/biology5040044
Received: 4 October 2016 / Revised: 10 November 2016 / Accepted: 14 November 2016 / Published: 19 November 2016
(This article belongs to the Special Issue Mechanisms of Mitotic Chromosome Segregation)
The spindle assembly checkpoint (SAC) is a quality control mechanism that ensures accurate chromosome segregation during cell division. It consists of a mechanochemical signal transduction mechanism that senses the attachment of chromosomes to the spindle, and a signaling cascade that inhibits cell division if one or more chromosomes are not attached. Extensive investigations of both these component systems of the SAC have synthesized a comprehensive understanding of the underlying molecular mechanisms. This review recounts the milestone results that elucidated the SAC, compiles a simple model of the complex molecular machinery underlying the SAC, and highlights poorly understood facets of the biochemical design and cell biological operation of the SAC that will drive research forward in the near future. View Full-Text
Keywords: mitosis; spindle assembly checkpoint; signal transduction; aneuploidy mitosis; spindle assembly checkpoint; signal transduction; aneuploidy
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Joglekar, A.P. A Cell Biological Perspective on Past, Present and Future Investigations of the Spindle Assembly Checkpoint. Biology 2016, 5, 44.

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