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The Function of Fish Cytokines

Scottish Fish Immunology Research Centre, University of Aberdeen, Zoology Building, Tillydrone Avenue, Aberdeen AB24 2TZ, UK
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Academic Editor: Brian Dixon
Biology 2016, 5(2), 23; https://doi.org/10.3390/biology5020023
Received: 29 February 2016 / Revised: 28 April 2016 / Accepted: 17 May 2016 / Published: 24 May 2016
(This article belongs to the Special Issue Current Understanding of Fish Immune Systems)
What is known about the biological activity of fish cytokines is reviewed. Most of the functional studies performed to date have been in teleost fish, and have focused on the induced effects of cytokine recombinant proteins, or have used loss- and gain-of-function experiments in zebrafish. Such studies begin to tell us about the role of these molecules in the regulation of fish immune responses and whether they are similar or divergent to the well-characterised functions of mammalian cytokines. This knowledge will aid our ability to determine and modulate the pathways leading to protective immunity, to improve fish health in aquaculture. View Full-Text
Keywords: cytokines; bioactivity; recombinant proteins; loss- and gain-of-function; interleukins; interferons; colony stimulating factors; tumour necrosis factors; transforming growth factor-β cytokines; bioactivity; recombinant proteins; loss- and gain-of-function; interleukins; interferons; colony stimulating factors; tumour necrosis factors; transforming growth factor-β
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Zou, J.; Secombes, C.J. The Function of Fish Cytokines. Biology 2016, 5, 23.

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