Next Article in Journal
Quadruplex-Forming Motif Inserted into 3′UTR of Ty1his3-AI Retrotransposon Inhibits Retrotransposition in Yeast
Next Article in Special Issue
PI3K as Mediator of Apoptosis and Contractile Dysfunction in TGFβ1-Stimulated Cardiomyocytes
Previous Article in Journal
A New Approach to Quantifying Bioaccumulation of Elements in Biological Processes
 
 
Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
Journals
Biology
Volume 10
Issue 4
10.3390/biology10040346
Review Report
biology-logo
Submit to this Journal Review for this Journal Propose a Special Issue
► Article Menu

Article Menu

share Share announcement Help format_quote Cite question_answer Discuss in SciProfiles
Review
Peer-Review Record

ERK1/2: An Integrator of Signals That Alters Cardiac Homeostasis and Growth

Biology 2021, 10(4), 346; https://doi.org/10.3390/biology10040346
by Christopher J. Gilbert †, Jacob Z. Longenecker † and Federica Accornero *
Reviewer 1: Anonymous
Reviewer 2:
Jiancheng Hu
Biology 2021, 10(4), 346; https://doi.org/10.3390/biology10040346
Submission received: 22 March 2021 / Revised: 15 April 2021 / Accepted: 16 April 2021 / Published: 20 April 2021
(This article belongs to the Special Issue Cardiac Protein Kinases as Homeostatic Molecular “Switches” and Regulators of Cell Fate)

Round 1

Reviewer 1 Report

This is a well-done, comprehensive review in the area of ERK signaling during cardiomyocyte function. I found the content to be very relevant (with historic as well as current citations) and interesting to those in the fields of cardiac function and kinase signaling. 

Author Response

We thank this reviewer for their appreciation of our work.

Reviewer 2 Report

In this manuscript, Gilbert et al summarized comprehensively the recent proceedings of how ERK signaling regulates cardiac homeostasis and growth, which would have significant impact on future studies in this field. Overall, it is an excellent review manuscript, but still can be further improved before publication. Here, I have three points below to help authors to improve their manuscript:

  1. Germline mutations in RAF family kinases cause cardiac developmental disorders. This is tightly related to the theme of this manuscript. Authors should discuss all related discoveries and their underlying mechanism in manuscript.
  2. One of important proceedings in the field of ERK signaling is the understanding of activation mechanism of RAF/MEK/ERK kinase cascade (Santos and Crespo, Sci Signal., 2018). A discussion within context of cardiac homeostasis and growth will significantly elevate the impact of this manuscript.
  3. Development of RAF inhibitors for cancer therapy is a very hot topic in current biomedical research. Do these inhibitors approved for clinic usage have any effects on cardiac homeostasis and growth ? if do, authors may briefly discuss in their manuscript.

Author Response

We thank this reviewer for their work in helping us improve this manuscript. As suggested, we now discuss the importance of RAF mutations as well as the effects of RAF inhibitors on the heart. We also now discuss the importance of understanding how protein-protein interactions upstream of ERK influence this signaling pathway. All the revisions made are tracked in the manuscript (pages 18-20). We appreciate this reviewer's advises.  

Back to TopTop