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Coatings 2019, 9(3), 164; https://doi.org/10.3390/coatings9030164

Polydopamine-Inspired Surface Modification of Polypropylene Hernia Mesh Devices via Cold Oxygen Plasma: Antibacterial and Drug Release Properties

1
College of Textiles and Fashion, Xinjiang University, 666 Sheng Li Road, Tian Shan, Wulumuqi 830046, China
2
Key Laboratory of Textile Science and Technology of Ministry of Education, Key Laboratory of Biomedical Textile Materials and Technology in Textile Industry, College of Textiles, Donghua University, 2999 North Renmin Road, Songjiang, Shanghai 201620, China
3
Department of Textile Engineering, Mehran University of Engineering and Technology, Jamshoro, Sindh 76062, Pakistan
4
Department of Surgery, University of Laval, Quebec, QC G1V 0A6, Canada
*
Authors to whom correspondence should be addressed.
Received: 20 December 2018 / Revised: 22 February 2019 / Accepted: 22 February 2019 / Published: 1 March 2019
(This article belongs to the Special Issue Advances in Antimicrobial Coatings)
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Abstract

Mesh infection is a major complication of hernia surgery after polypropylene (PP) mesh implantation. Modifying the PP mesh with antibacterial drugs is an effective way to reduce the chance of infection, but the hydrophobic characteristic of PP fibers has obstructed the drug adhesion. Therefore, to prepare antimicrobial PP mesh with a stable drug coating layer and to slow the drug release property during the hernia repair process has a great practical meaning. In this work, PP meshes were coated by bio-inspired polydopamine (PDA), which can load and release levofloxacin. PP meshes were activated with cold oxygen plasma and then plasma activated PP fibers were coated with PDA. The PDA coated meshes were further soaked in levofloxacin. The levofloxacin loaded PP meshes demonstrate excellent antimicrobial properties for 6 days and the drug release has lasted for at least 24 h. Moreover, a control PP mesh sample without plasma treatment was also prepared, after coating with PDA and loading levofloxacin. The antimicrobial property was sustained only for two days. The maximum inhibition zone of PDA coated meshes with and without plasma treatment was 12.5 and 9 mm, respectively. On all accounts, the modification strategy can facilely lead to long-term property of infection prevention. View Full-Text
Keywords: polypropylene; hernia meshes; antibacterial; drug release; polydopamine polypropylene; hernia meshes; antibacterial; drug release; polydopamine
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Saitaer, X.; Sanbhal, N.; Qiao, Y.; Li, Y.; Gao, J.; Brochu, G.; Guidoin, R.; Khatri, A.; Wang, L. Polydopamine-Inspired Surface Modification of Polypropylene Hernia Mesh Devices via Cold Oxygen Plasma: Antibacterial and Drug Release Properties. Coatings 2019, 9, 164.

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