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Coatings 2019, 9(3), 168; https://doi.org/10.3390/coatings9030168

Chitosan Cross-Linked Bio-based Antimicrobial Polypropylene Meshes for Hernia Repair Loaded with Levofloxacin HCl via Cold Oxygen Plasma

1
Key Laboratory of Textile Science and Technology of Ministry of Education, College of Textiles, Donghua University, 2999 North Renmin Road, Songjiang, Shanghai 201620, China
2
Department of Textile Engineering, Mehran University of Engineering and Technology, Jamshoro 76062, Sindh, Pakistan
*
Authors to whom correspondence should be addressed.
Received: 18 December 2018 / Revised: 19 February 2019 / Accepted: 26 February 2019 / Published: 4 March 2019
(This article belongs to the Special Issue Advances in Antimicrobial Coatings)
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Abstract

Polypropylene (PP) large pore size nets have been most widely used implants for hernia repair. Nevertheless, the growth of bacteria within PP mesh pores after operation is a major reason of hernia recurrence. Secondly, pre-operative prophylaxis during mesh implantation has failed due to the hydrophobic nature of PP meshes. Herein, chitosan cross-linked and levofloxacin HCl incorporated, antimicrobial PP mesh devices were prepared using citric acid as a bio-based and green cross-linking agent. The inert PP mesh fibers were surface activated using O2 plasma treatment at low pressure. Then, chitosan of different molecular weights (low and medium weight) were cross-linked with O2 plasma activated surfaces using citric acid. Scanning electron microscopy (SEM), energy dispersive X-ray (EDX) spectroscopy, and Fourier transform infrared (FTIR) spectroscopy confirmed that chitosan was cross-linked with O2 plasma-treated PP mesh surfaces and formed a thin layer of chitosan and levofloxacin HCl on the PP mesh surfaces. Moreover, antimicrobial properties of chitosan and levofloxacin HCl-coated PP meshes were investigated using an agar plate release method. The coated PP meshes demonstrated excellent antimicrobial inhibition zone up to 10 mm. Thus, modified PP meshes demonstrated sustained antimicrobial properties for six continuous days against Staphylococcus aureus (SA) and Escherichia coli (EC) bacteria. View Full-Text
Keywords: antimicrobial; polypropylene; chitosan; citric acid; cross-linked; cold plasma antimicrobial; polypropylene; chitosan; citric acid; cross-linked; cold plasma
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Sanbhal, N.; Li, Y.; Khatri, A.; Peerzada, M.; Wang, L. Chitosan Cross-Linked Bio-based Antimicrobial Polypropylene Meshes for Hernia Repair Loaded with Levofloxacin HCl via Cold Oxygen Plasma. Coatings 2019, 9, 168.

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