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Article

Effect of Micelle Encapsulation on Toxicity of CdSe/ZnS and Mn-Doped ZnSe Quantum Dots

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William G. Lowrie Department of Chemical and Biomolecular Engineering, The Ohio State University, 151 W. Woodruff Ave., Columbus, OH 43210, USA
2
Department of Biomedical Engineering, The Ohio State University, 151 W. Woodruff Ave., Columbus, OH 43210, USA
*
Author to whom correspondence should be addressed.
Academic Editor: Anton Ficai
Coatings 2021, 11(8), 895; https://doi.org/10.3390/coatings11080895
Received: 30 May 2021 / Revised: 6 July 2021 / Accepted: 20 July 2021 / Published: 26 July 2021
The optical properties of quantum dots (QD) make them excellent candidates for bioimaging, biosensing, and therapeutic applications. However, conventional QDs are comprised of heavy metals (e.g., cadmium) that pose toxicity challenges in biological systems. Synthesising QDs without heavy metals or introducing thick surface coatings, e.g., by encapsulation in micelles, can reduce toxicity. Here, we examined the toxicity of micelle encapsulated tetrapod-shaped Mn-doped ZnSe QDs, comparing them to 3-mercaptopropionic acid (MPA)-capped Mn-doped ZnSe QDs prepared by ligand exchange and commercial CdSe/ZnS QD systems that were either capped with MPA or encapsulated in micelles. HepG2 cell treatment with MPA-coated CdSe/ZnS QDs resulted in a dose-dependent reduction of viability (MTT assay, treatment at 0–25 μg/mL). Surprisingly, no reactive oxygen species (ROS) or apoptotic signaling was observed, despite evidence of apoptotic behavior in flow cytometry. CdSe/ZnS QD micelles showed minimal toxicity at doses up to 25 μg/mL, suggesting that thicker protective polymer layers reduce cytotoxicity. Despite their shape, neither MPA- nor micelle-coated Mn-doped ZnSe QDs displayed a statistically significant toxicity response over the doses investigated, suggesting these materials as good candidates for bioimaging applications. View Full-Text
Keywords: toxicity; cadmium-free; doped; micelle; quantum dots toxicity; cadmium-free; doped; micelle; quantum dots
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MDPI and ACS Style

Fan, Q.; Dehankar, A.; Porter, T.K.; Winter, J.O. Effect of Micelle Encapsulation on Toxicity of CdSe/ZnS and Mn-Doped ZnSe Quantum Dots. Coatings 2021, 11, 895. https://doi.org/10.3390/coatings11080895

AMA Style

Fan Q, Dehankar A, Porter TK, Winter JO. Effect of Micelle Encapsulation on Toxicity of CdSe/ZnS and Mn-Doped ZnSe Quantum Dots. Coatings. 2021; 11(8):895. https://doi.org/10.3390/coatings11080895

Chicago/Turabian Style

Fan, Qirui, Abhilasha Dehankar, Thomas K. Porter, and Jessica O. Winter 2021. "Effect of Micelle Encapsulation on Toxicity of CdSe/ZnS and Mn-Doped ZnSe Quantum Dots" Coatings 11, no. 8: 895. https://doi.org/10.3390/coatings11080895

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