Next Article in Journal
Effect of Carrier Gas Flow Field on Chemical Vapor Deposition of 2D MoS2 Crystal
Next Article in Special Issue
Addendum: Gilani et al. Formulation and Optimization of Nano Lipid Based Oral Delivery Systems for Arthritis. Coatings 2021, 11, 548
Previous Article in Journal
Surface and Interface Investigation of a 15th Century Wall Painting Using Multispectral Imaging and Pulse-Compression Infrared Thermography
Previous Article in Special Issue
A Facile Urea-Assisted Thermal Decomposition Process of TiO2 Nanoparticles and Their Photocatalytic Activity
Addendum published on 30 June 2021, see Coatings 2021, 11(7), 781.
Article

Formulation and Optimization of Nano Lipid Based Oral Delivery Systems for Arthritis

1
Department of Basic Health Sciences, Preparatory Year, Princess Nourah bint Abdulrahman University, Riyadh 11671, Saudi Arabia
2
Biology Department, College of Science, Princess Nourah bint Abdulrahman University, Riyadh 11671, Saudi Arabia
3
Environment and Biomaterial Unit, Health Sciences Research Center, Princess Nourah bint Abdulrahman University, Riyadh 11671, Saudi Arabia
4
Department of Pharmaceutics, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia
5
Department of Pharmaceutics, Nibha Institute of Pharmaceutical Sciences, Rajgir 803116, India
6
Department of Pharmaceutics, College of Pharmacy, Jouf University, Aljouf Region 72341, Saudi Arabia
*
Author to whom correspondence should be addressed.
Academic Editor: Keith J. Stine
Coatings 2021, 11(5), 548; https://doi.org/10.3390/coatings11050548
Received: 23 March 2021 / Revised: 25 April 2021 / Accepted: 29 April 2021 / Published: 6 May 2021
Rheumatoid arthritis is an autoimmune disease characterized by chronic synovitis that leads to tissue dysfunction as well as loss of complete function. There are several synthetic NSAIDs, glucocorticoids and biological drugs that are commonly used to treat arthritis. These drugs have severe life-threatening side effects. The use of a bioactive compound (Apigenin) could be an alternative to synthetic conventional delivery systems. It is a poorly water-soluble drug having a wide range of pharmacological activities. It has been reported for potential anti-inflammatory and anti-arthritic activity. In the present study, Apigenin (APG) solid lipid nanoparticles were prepared using the solid lipid (glyceryl mono stearate, GMS), surfactant (d -α-Tocopheryl polyethylene glycol 1000 succinate, TPGS) and sonication time (ST). The optimized APG SLNs showed a particle size of 161.7 nm and encapsulation efficiency of 80.44 ± 4.11%. It was further coated with 0.1% w/v chitosan (APG-CH-SLNs) and showed the particle size, PDI and zeta potential of 185.4 nm, 0.45 + 26.7 mV, respectively. The significant (p < 0.001) enhancement in drug release, permeation and mucoadhesive study was observed after chitosan coating. The antioxidant study results depicted an increase in antioxidant property. Finally, the anti-arthritic biochemical parameters revealed marked changes in the results in comparison to arthritic control animals. From the study, it was concluded that APG-loaded mucoadhesive lipid nanoparticles are an alternative to the synthetic oral delivery systems. View Full-Text
Keywords: apigenin; SLNs; chitosan; arthritis; antioxidant; biochemical parameters apigenin; SLNs; chitosan; arthritis; antioxidant; biochemical parameters
Show Figures

Figure 1

MDPI and ACS Style

Gilani, S.J.; Bin-Jumah, M.N.; Imam, S.S.; Alshehri, S.; Jahangir, M.A.; Zafar, A. Formulation and Optimization of Nano Lipid Based Oral Delivery Systems for Arthritis. Coatings 2021, 11, 548. https://doi.org/10.3390/coatings11050548

AMA Style

Gilani SJ, Bin-Jumah MN, Imam SS, Alshehri S, Jahangir MA, Zafar A. Formulation and Optimization of Nano Lipid Based Oral Delivery Systems for Arthritis. Coatings. 2021; 11(5):548. https://doi.org/10.3390/coatings11050548

Chicago/Turabian Style

Gilani, Sadaf J., May N. Bin-Jumah, Syed S. Imam, Sultan Alshehri, Mohammed A. Jahangir, and Ameeduzzafar Zafar. 2021. "Formulation and Optimization of Nano Lipid Based Oral Delivery Systems for Arthritis" Coatings 11, no. 5: 548. https://doi.org/10.3390/coatings11050548

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop