PLGA Coatings and PLGA Drug-Loading Coatings for Cardiac Stent Samples: Degradation Characteristics and Blood Compatibility
Abstract
:1. Introduction
2. Experimental Method
2.1. Preparation
2.2. Morphology and Thermal Property Test
2.3. Degradation Characteristics
2.4. Platelet Adhesion Test
2.5. Dynamic Coagulation Time
3. Results and Discussion
3.1. SEM, DSC, and XRD Measurements of PLGA Drug-Loading Coatings
3.2. Degradation Characteristics of PLGA Drug-Loading Coatings
3.3. Blood Compatibility Analyses of PLGA Drug-Loading Coatings
4. Conclusions
- (1)
- PLGA and PLGA coatings with RAPA levels of 33%, 50%, and 66% were successfully prepared on the surface of 316 L stainless steel. SEM results demonstrated that when the RAPA level was 33%, the drug-loading coating morphology was smooth and flat, which was similar to that of the pure PLGA coating. DSC results indicated the melting peak was observed upon the addition of RAPA, and the melting heat of the coating increased with drug level increases, and the drug existed in a microcrystalline form.
- (2)
- No characteristic peaks from the drug crystal were observed in the XRD results, and the drug-loading coating was still amorphous. RAPA addition decreased the Tg of the PLGA coating, accompanied by partial crystallization that reduced the degradation rate of the drug loading coating.
- (3)
- The number of platelets adhered to the PLGA drug-loading coating surface was significantly less than for the PLGA coating, and there was no deformation or pseudopodia. The coagulation time of the drug-loading coating was longer, and the activation degree of the coagulation factor minimized when the RAPA content was 50%. The microphase separation structure was generated by mixing RAPA and PLGA, which effectively increased the critical tension and reduced the free energy of the crystal plane to improve the blood compatibility of the coating.
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Time | PLGA | 33%-RAPA-PLGA | ||
---|---|---|---|---|
(Weeks) | Remaining Weight (%) | pH | Remaining Weight (%) | pH |
0 | 100 | 7.5 | 100 | 7.6 |
1 | 90.3 | 7.4 | 88.2 | 7.5 |
2 | 88.7 | 7.4 | 85.8 | 7.5 |
5 | 87.6 | 7.4 | 87.1 | 7.4 |
8 | 83.5 | 5.5 | 84.6 | 5.8 |
11 | 43.3 | 5.0 | 80.5 | 5.7 |
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Jia, Z.; Ma, C.; Zhang, H. PLGA Coatings and PLGA Drug-Loading Coatings for Cardiac Stent Samples: Degradation Characteristics and Blood Compatibility. Coatings 2021, 11, 1427. https://doi.org/10.3390/coatings11111427
Jia Z, Ma C, Zhang H. PLGA Coatings and PLGA Drug-Loading Coatings for Cardiac Stent Samples: Degradation Characteristics and Blood Compatibility. Coatings. 2021; 11(11):1427. https://doi.org/10.3390/coatings11111427
Chicago/Turabian StyleJia, Ziyang, Chunyang Ma, and Hongbin Zhang. 2021. "PLGA Coatings and PLGA Drug-Loading Coatings for Cardiac Stent Samples: Degradation Characteristics and Blood Compatibility" Coatings 11, no. 11: 1427. https://doi.org/10.3390/coatings11111427