Protruding Nanostructured Surfaces for Antimicrobial and Osteogenic Titanium Implants
Round 1
Reviewer 1 Report
The paper is well organized and contain the most important things about dental implants
Comments for author File: 
Comments.docx
Author Response
We appreciate the reviewer’s reflection on our manuscript and for the supportive comments.
Reviewer 2 Report
I am honored to take part in the review process of this article. It is a so relevant question in the modern literature.
I found it very interesting, I like so much this topic. I suggest You to add more topics in the introduction and discussion sections; for example you can debate about the relationship with some topics as in this studies and cite them: https://doi.org/10.3390/jcm9051264 ; https://doi.org/10.3390/antibiotics9040179 ;
https://doi.org/10.26355/eurrev_201807_15392 ;
https://doi.org/10.3390/antibiotics9050234 ;
https://doi.org/10.3390/antibiotics9030110
I suggest a moderate English and grammar revision
Check the references section to be in order to journal style.
Author Response
We thank the reviewer for these supportive comments.
Please see the attachment for our responses.
Author Response File: Author Response.docx
Reviewer 3 Report
The manuscript is very interesting, reviewing the state-of-the-art of protruding nanostructured surfaces and their antimicrobial/osteogenic properties, with applications in titanium implants improvement. Different nanofabrication methods and the mechanisms of action on various microorganisms are presented. Overall, the manuscript is well written and well organized, in a good English style.
However, minor revision should be made:
- Some references were not recognized by the software used and appear as errors in the manuscript (lines 117, 146, 151, 157, 162, 166, 172, 211, 213, 303, 336, 358, 392).
- A reference is needed for line 113-114 and 318-319.
- Please explain what the abbreviations mean in lines 180, 252, 265, 269, 275.
- Line 322: “in vivo” should be italicized.
- A reference to each figure should be also introduced in text explaining what it represents and the source of the figure must be explicitly mentioned.
Author Response
We thank the reviewer for these supportive comments.
Please see the attachment for our responses.
Author Response File: Author Response.docx
Reviewer 4 Report
Thank you for the opportunity of peer-reviewing this manuscript.
Citation and references – please cite every single sentence, do not leave any sentence without citation. Therefore please review your reference list, otherwise publication is unacceptable. There are some references that are shown not to be verified. Please be sure every single citation is verifiable in Web of science - WOS.
Considerations: This is an interesting subject and a comprehensive review. If the references and citation issues can be addressed the article should be considered for publication.
Best regards,
Author Response
We thank the reviewer for these supportive comments.
Please see the attachment for our responses.
Author Response File: Author Response.docx
Reviewer 5 Report
I read your manuscript with interest.
Please follow the next indications to enhance your manuscript:
Improve the background information used in the introduction and discussion
Introduction
line 44 “Implant failures are” please add the reference.
Line 55 This is an important issue in implantology please add more information on the influence of temperature modifications induced during implant site preparation and implant failure.
Line 79 Please add other strategy for control of bacterial adhesion, for example anatase, nanocoating with hydrosilver etc..
Line 329 I suggest to add more information on the influence of the thermal treatment for address a better osseointegration.
Author Response
We thank the reviewer for these supportive comments.
Please see the attachment for our responses.
Author Response File: Author Response.docx
