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Article

Safety and Local Efficacy of Laser Ablation for the Extrahepatic Metastasis of Hepatocellular Carcinoma: An Available Treatment Strategy

1
Department of Medical Ultrasound, Division of Interventional Ultrasound, the First Affiliated Hospital, Sun Yat-sen University, No. 58 Zhongshan 2nd Road, Guangzhou 510080, China
2
Department of Medical Oncology, the First Affiliated Hospital, Sun Yat-sen University, No. 58 Zhongshan 2nd Road, Guangzhou 510080, China
*
Author to whom correspondence should be addressed.
Coatings 2020, 10(10), 951; https://doi.org/10.3390/coatings10100951
Received: 28 August 2020 / Revised: 28 September 2020 / Accepted: 28 September 2020 / Published: 1 October 2020
(This article belongs to the Special Issue Thin Film Laser Damage, Ablation, Deposition and Structuring)
Thermal ablation plays an important role in the treatment of extrahepatic metastasis of hepatocellular carcinoma (HCC). Yet laser ablation (LA), as a safe thermal ablative modality, is less investigated in this field. In this study, the safety and local effectiveness of LA in the treatment for the extrahepatic metastasis of HCC were evaluated. From May 2012 to May 2019, 17 patients (13 males and 4 females; mean age, 54.1 ± 14.6 years; age range, 34–80 years), who underwent LA for treatment of extrahepatic metastasis of HCC at the First Affiliated Hospital of Sun Yat-sen University, were retrospectively enrolled in this study. Local effectiveness, complications, local tumor progression (LTP), and overall survival (OS) were evaluated. Finally, a total of 28 LA treated extrahepatic metastatic lesions of HCC were reviewed. Neither LA-related mortality nor major complication occurred. Complete ablation (CA) was achieved in 20 out of 28 lesions (71.4%). During the follow-up (mean, 19.5 ± 12.8 months; range, 5–42.7 months), LTP developed in 4 out of 20 lesions with CA (20%). Four patients died of tumor progression or multiple organ dysfunction syndrome. The accumulative one- and three-year OS rates were 79.0% and 65.8%, respectively. In conclusion, LA is a safe and effective therapeutic option in the treatment of extrahepatic metastasis of HCC. Further studies are necessary to evaluate the benefit of LA. View Full-Text
Keywords: laser ablation; hepatocellular carcinoma; extrahepatic metastasis; safety; local efficacy laser ablation; hepatocellular carcinoma; extrahepatic metastasis; safety; local efficacy
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MDPI and ACS Style

Long, H.; Zhuang, B.; Huang, G.; Li, X.; Lin, M.; Long, J.; Xie, X.; Liu, B. Safety and Local Efficacy of Laser Ablation for the Extrahepatic Metastasis of Hepatocellular Carcinoma: An Available Treatment Strategy. Coatings 2020, 10, 951. https://doi.org/10.3390/coatings10100951

AMA Style

Long H, Zhuang B, Huang G, Li X, Lin M, Long J, Xie X, Liu B. Safety and Local Efficacy of Laser Ablation for the Extrahepatic Metastasis of Hepatocellular Carcinoma: An Available Treatment Strategy. Coatings. 2020; 10(10):951. https://doi.org/10.3390/coatings10100951

Chicago/Turabian Style

Long, Haiyi, Bowen Zhuang, Guangliang Huang, Xiaoju Li, Manxia Lin, Jianting Long, Xiaoyan Xie, and Baoxian Liu. 2020. "Safety and Local Efficacy of Laser Ablation for the Extrahepatic Metastasis of Hepatocellular Carcinoma: An Available Treatment Strategy" Coatings 10, no. 10: 951. https://doi.org/10.3390/coatings10100951

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