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Open AccessFeature PaperArticle

Silver-Doped Hydroxyapatite Thin Layers Obtained by Sol-Gel Spin Coating Procedure

Carol Davila University of Medicine and Pharmacy, 8 Eroii Sanitari, Sector 5, 050474 Bucharest, Romania
Emergency Hospital Floreasca Bucharest, 8 Calea Floresca, 014461 Bucharest, Romania
National Institute of Materials Physics, Atomistilor Street, No. 405A, P.O. Box MG 07, 077125 Magurele, Romania
University Politehnica of Bucharest, BN 002, 313 Splaiul Independentei, Sector 6, 060042 Bucharest, Romania
ISTO, UMR 7327 CNRS Université d’Orléans, 1A rue de la Férollerie, 45071 Orléans CEDEX 2, France
Author to whom correspondence should be addressed.
Coatings 2020, 10(1), 14;
Received: 27 November 2019 / Revised: 20 December 2019 / Accepted: 23 December 2019 / Published: 25 December 2019
(This article belongs to the Special Issue Biomedical Applications of Functional Nanoparticles)
The main objective of this paper is to develop silver-doped hydroxyapatite suspensions (HApAg) with different concentrations of silver (?Ag = 0.05 and ?Ag = 0.2) in order to obtain uniform and homogenous layers by spin-coating procedure. The colloidal properties of HApAg suspensions are evaluated by dynamic light scattering (DLS) analysis, ζ-potential (ZP), and ultrasound measurements. The ultrasound studies show that the HApAg20 sample revealed better stability than the HApAg5 sample. The structural and morphological analysis on suspensions and thin layers is also conducted. It is observed that the particles of the two samples have a similar shape and are uniform. The layers obtained present a homogeneous appearance of the surface without evidence of cracks or interruption of the coatings. The in vitro antifungal studies conducted on the two thin layers at two different time intervals (24 and 48 h) show that both HApAg5 (?Ag = 0.05) and HApAg20 (?Ag = 0.05) nanoparticles suspensions and composite layers inhibit the development of colony forming units (CFU) even after 24 h of incubation comparative to the control, represented by the Candida albicans (C. albicans) culture in a proper medium. The fungicidal effect was evident after 48 h of incubation in the case of both HApAg20 nanoparticles suspensions and composite layers. View Full-Text
Keywords: silver; hydroxyapatite; suspension stability; sol-gel spin coating; antimicrobial properties silver; hydroxyapatite; suspension stability; sol-gel spin coating; antimicrobial properties
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MDPI and ACS Style

Prodan, A.M.; Iconaru, S.L.; Predoi, M.V.; Predoi, D.; Motelica-Heino, M.; Turculet, C.S.; Beuran, M. Silver-Doped Hydroxyapatite Thin Layers Obtained by Sol-Gel Spin Coating Procedure. Coatings 2020, 10, 14.

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