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Article

Antimicrobial Effect of Natural Berry Juices on Common Oral Pathogenic Bacteria

1
Department of Conservative Dentistry and Periodontology, Jena University Hospital, Friedrich-Schiller-University, An der Alten Post 4, 07743 Jena, Germany
2
Institute for Medical Microbiology, University Hospital Jena, Erlanger Allee 101, 07747 Jena, Germany
*
Author to whom correspondence should be addressed.
Antibiotics 2020, 9(9), 533; https://doi.org/10.3390/antibiotics9090533
Received: 31 July 2020 / Revised: 14 August 2020 / Accepted: 20 August 2020 / Published: 24 August 2020
(This article belongs to the Special Issue Alternatives to Antibiotics in Dentistry)
(1) Background: Antimicrobial agents such as chlorhexidine (CHX) are commonly used in oral plaque control. However, sometimes those agents lack antimicrobial efficiency or cause undesired side effects. To identify alternative anti-infective agents, the present study investigated the antibacterial activity of all-fruit juices derived from blackcurrant, redcurrant, cranberry and raspberry on common oral pathogenic gram-positive and gram-negative bacteria (Streptococcus mutans, Streptococcus gordonii, Streptococcus sobrinus, Actinomyces naeslundii, Fusobacterium nucleatum, Aggregatibacter actinomycetemcomitans, Porphyromonas gingivalis, Enterococcus faecalis). (2) Methods: Antibacterial efficiency was evaluated by agar diffusion assay and in direct contact with bacteria in planktonic culture. Furthermore, cytotoxicity on human gingival fibroblasts was determined. (3) Results: Blackcurrant juice was most efficient at suppressing bacteria; followed by the activity of redcurrant and cranberry juice. Raspberry juice only suppressed P. gingivalis significantly. Only high-concentrated blackcurrant juice showed minimal cytotoxic effects which were significantly less compared to the action of CHX. (4) Conclusion: Extracts from natural berry juices might be used for safe and efficient suppression of oral pathogenic bacterial species. View Full-Text
Keywords: ribes nigrum; ribes rubrum; rubus idaeus; vaccinium macrocarpon; chlorhexidine; antibacterial agents; cytotoxicity; oral plaque bacteria; periodontitis ribes nigrum; ribes rubrum; rubus idaeus; vaccinium macrocarpon; chlorhexidine; antibacterial agents; cytotoxicity; oral plaque bacteria; periodontitis
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MDPI and ACS Style

Kranz, S.; Guellmar, A.; Olschowsky, P.; Tonndorf-Martini, S.; Heyder, M.; Pfister, W.; Reise, M.; Sigusch, B. Antimicrobial Effect of Natural Berry Juices on Common Oral Pathogenic Bacteria. Antibiotics 2020, 9, 533. https://doi.org/10.3390/antibiotics9090533

AMA Style

Kranz S, Guellmar A, Olschowsky P, Tonndorf-Martini S, Heyder M, Pfister W, Reise M, Sigusch B. Antimicrobial Effect of Natural Berry Juices on Common Oral Pathogenic Bacteria. Antibiotics. 2020; 9(9):533. https://doi.org/10.3390/antibiotics9090533

Chicago/Turabian Style

Kranz, Stefan, André Guellmar, Philipp Olschowsky, Silke Tonndorf-Martini, Markus Heyder, Wolfgang Pfister, Markus Reise, and Bernd Sigusch. 2020. "Antimicrobial Effect of Natural Berry Juices on Common Oral Pathogenic Bacteria" Antibiotics 9, no. 9: 533. https://doi.org/10.3390/antibiotics9090533

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