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Review

Current Antimycotics, New Prospects, and Future Approaches to Antifungal Therapy

Department of Biology and The South Texas Center for Emerging Infectious Diseases, The University of Texas at San Antonio, One UTSA Circle, San Antonio, TX 78249, USA
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Antibiotics 2020, 9(8), 445; https://doi.org/10.3390/antibiotics9080445
Received: 30 June 2020 / Revised: 22 July 2020 / Accepted: 23 July 2020 / Published: 25 July 2020
(This article belongs to the Special Issue Fungal Pathogens: Resistance and Novel Therapeutics)
Fungal infections represent an increasing threat to a growing number of immune- and medically compromised patients. Fungi are eukaryotic organisms and, as such, there is a limited number of selective targets that can be exploited for antifungal drug development. This has also resulted in a very restricted number of antifungal drugs that are clinically available for the treatment of invasive fungal infections at the present time—polyenes, azoles, echinocandins, and flucytosine. Moreover, the utility of available antifungals is limited by toxicity, drug interactions and the emergence of resistance, which contribute to high morbidity and mortality rates. This review will present a brief summary on the landscape of current antifungals and those at different stages of clinical development. We will also briefly touch upon potential new targets and opportunities for novel antifungal strategies to combat the threat of fungal infections. View Full-Text
Keywords: fungal infections; antifungal agents; antifungal drug development fungal infections; antifungal agents; antifungal drug development
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MDPI and ACS Style

Wall, G.; Lopez-Ribot, J.L. Current Antimycotics, New Prospects, and Future Approaches to Antifungal Therapy. Antibiotics 2020, 9, 445. https://doi.org/10.3390/antibiotics9080445

AMA Style

Wall G, Lopez-Ribot JL. Current Antimycotics, New Prospects, and Future Approaches to Antifungal Therapy. Antibiotics. 2020; 9(8):445. https://doi.org/10.3390/antibiotics9080445

Chicago/Turabian Style

Wall, Gina, and Jose L. Lopez-Ribot. 2020. "Current Antimycotics, New Prospects, and Future Approaches to Antifungal Therapy" Antibiotics 9, no. 8: 445. https://doi.org/10.3390/antibiotics9080445

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