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Article

Longitudinal Point Prevalence Survey of Antimicrobial Consumption in Russian Hospitals: Results of the Global-PPS Project

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Internal Medicine Department, First Moscow State Medical University, 119991 Moscow, Russia
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Institute of Antimicrobial Chemotherapy, Smolensk State Medical University, 214019 Smolensk, Russia
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Vaccine & Infectious Disease Institute, University of Antwerp, 2610 Antwerp, Belgium
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Department of Pharmacology and Pharmaceutical Consulting, Krasnoyarsk State Medical University n.a. Professor V. F. Voyno-Yasenetsky, 660022 Krasnoyarsk, Russia
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Kuzbas Children’s Clinical Hospital n.a. Professor Y. Е. Malachovskiy, 654063 Novokuznetsk, Russia
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Omsk Regional Clinical Hospital, 644111 Omsk, Russia
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City Clinical Hospital n.a. V. V. Vinogradov, 117292 Moscow, Russia
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Federal Centre of Traumatology, Orthopedics and Endoprosthesis Replacement, 214019 Smolensk, Russia
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Regional Clinical Hospital no.2, 350012 Krasnodar, Russia
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National Medical Research Center for Cardiovascular Surgery n.a. A.N. Bakulev, 121552 Moscow, Russia
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Department of Internal Medicine and General Medical Practice (Family Medicine), North-Eastern Federal University, 677007 Yakutsk, Russia
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Department of Pathological Physiology, Stavropol State Medical University, 355017 Stavropol, Russia
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Republican Clinical Hospital n.a. N.A. Semashko, 670031 Ulan-Ude, Russia
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Tomsk Regional Clinical Hospital, 634063 Tomsk, Russia
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Republican Children’s Hospital, 185000 Petrozavodsk, Russia
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General Surgery Department #1, Perm State Medical University n.a. E.A. Vagner, 614000 Perm, Russia
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Author to whom correspondence should be addressed.
Andrey Anikeev (RUDN University, Moscow, Russian Federation), Maria Dondokova (Republican Clinical Hospital n.a. N.A. Semashko, Ulan-Ude, Russian Federation), Anastasiya Egorova (Tomsk Regional Clinical Hospital, Tomsk, Russian Federation), Elena Khvashchevskaya (Tomsk Regional Clinical Hospital, Tomsk, Russian Federation), Vladlen Kostin (Republican Children’s Hospital, Petrozavodsk, Russian Federation), Evgenia Kurtz (Krasnoyarsk Regional Clinical Hospital, Krasnoyarsk, Russian Federation), Natalia Matveeva (Kuzbas Children’s Clinical Hospital n.a. Professor Y. Е. Malachovskiy, Novokuznetsk, Russian Federation), Ekaterina Roschina (RUDN University, Moscow, Russian Federation), Irina Shevchik (Smolensk State Medical University, Smolensk, Russian Federation), Darya Shodorova (Republican Clinical Hospital n.a. N.A. Semashko, Ulan-Ude, Russian Federation), Аlexey Tolpygo (Smolensk Regional Clinical Hospital, Smolensk, Russian Federation), Alina Vinogradova (Smolensk State Medical University, Smolensk, Russian Federation), Daria Zabolotnaya (RUDN University, Moscow, Russian Federation), Ivan Zakharenkov (Bryansk city hospital №1, Bryansk, Russian Federation).
Antibiotics 2020, 9(8), 446; https://doi.org/10.3390/antibiotics9080446
Received: 1 July 2020 / Revised: 21 July 2020 / Accepted: 22 July 2020 / Published: 25 July 2020
Antimicrobial resistance is one of the key issues limiting the successful treatment of infectious diseases and associated with adverse medical, social and economic consequences on a global scale. The present study aims to evaluate antimicrobials prescribing patterns and assess progress in quality indicators in Russian multidisciplinary hospitals using three repetitive point prevalence studies (PPSs) over 4 years (Global-PPS 2015, 2017 and 2018). Out of 13,595 patients from 21 hospitals surveyed over the three time points, 3542 (26.14%) received antimicrobials, predominantly third-generation cephalosporins (44.7% in 2015, 34.1% in 2017 and 41.8% in 2018). Compliance with the hospital antibiotic guidelines was 74.8%, 66.8% and 74.3%, respectively. Indication for treatment was recorded in 72.6%, 84.1% and 82.6%, while stop/review date was documented only in 40.5%, 46.5% and 61.1% of cases. Perioperative antibiotic prophylaxis exceeded 1 day in 92%, 84% and 81% of cases. Targeted therapy rate at all time points did not exceed 15.1%, treatment based on the biomarkers rate—19.9%. For the part of PPS-2017 and 2018 analyzed in dynamics, no prominent trends were noted. The results of the project provide the basis for the development of appropriate antimicrobial stewardship programs tailored according to local practices for each hospital in the project. View Full-Text
Keywords: antimicrobials; pharmacoepidemiology; point prevalence survey; inpatients antimicrobials; pharmacoepidemiology; point prevalence survey; inpatients
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MDPI and ACS Style

Rachina, S.; Belkova, Y.; Kozlov, R.; Versporten, A.; Pauwels, I.; Goossens, H.; Bochanova, E.; Domanskaya, O.; Elokhina, E.; Ezhova, L.; Mishchenko, V.; Ni, O.; Popov, D.; Portnjagina, U.; Shchetinin, E.; Shegimova, V.; Strezh, Y.; Vityazeva, V.; Zubareva, N.; Russian Global-PPS Project Study Group. Longitudinal Point Prevalence Survey of Antimicrobial Consumption in Russian Hospitals: Results of the Global-PPS Project. Antibiotics 2020, 9, 446. https://doi.org/10.3390/antibiotics9080446

AMA Style

Rachina S, Belkova Y, Kozlov R, Versporten A, Pauwels I, Goossens H, Bochanova E, Domanskaya O, Elokhina E, Ezhova L, Mishchenko V, Ni O, Popov D, Portnjagina U, Shchetinin E, Shegimova V, Strezh Y, Vityazeva V, Zubareva N, Russian Global-PPS Project Study Group. Longitudinal Point Prevalence Survey of Antimicrobial Consumption in Russian Hospitals: Results of the Global-PPS Project. Antibiotics. 2020; 9(8):446. https://doi.org/10.3390/antibiotics9080446

Chicago/Turabian Style

Rachina, Svetlana, Yuliya Belkova, Roman Kozlov, Ann Versporten, Ines Pauwels, Herman Goossens, Elena Bochanova, Olga Domanskaya, Elena Elokhina, Ludmila Ezhova, Vladimir Mishchenko, Oksana Ni, Dmitry Popov, Ulyana Portnjagina, Evgeny Shchetinin, Vera Shegimova, Yulia Strezh, Vera Vityazeva, Nadezhda Zubareva, and Russian Global-PPS Project Study Group. 2020. "Longitudinal Point Prevalence Survey of Antimicrobial Consumption in Russian Hospitals: Results of the Global-PPS Project" Antibiotics 9, no. 8: 446. https://doi.org/10.3390/antibiotics9080446

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