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Antimicrobial Stewardship: From Bedside to Theory. Thirteen Examples of Old and More Recent Strategies from Everyday Clinical Practice

1
Department of Medical, Surgical and Health Sciences, Trieste University, 34127 Trieste, Italy
2
Department of Infectious Diseases, University Medical Centre Ljubljana, 1000 Ljubljana, Slovenia
3
Infectious Disease Unit, Azienda Ospedaliero-Universitaria Senese, 53100 Siena, Italy
4
Azienda Sanitaria Universitaria Giuliano Isontina, 34128 Trieste, Italy
*
Author to whom correspondence should be addressed.
Antibiotics 2020, 9(7), 398; https://doi.org/10.3390/antibiotics9070398
Received: 10 June 2020 / Revised: 7 July 2020 / Accepted: 8 July 2020 / Published: 10 July 2020
“Antimicrobial stewardship” is a strategy that promotes the responsible use of antimicrobials. The objective of this paper is to focus on consolidated and more recent improvements in clinical strategies that should be adopted in hospitalized patients to ameliorate their infectious diseases’ outcome and to reduce the antibiotic resistance risk through judicious use of antibiotics. We present 13 common clinical scenarios, the respective suggested interventions and the explanations of the supporting evidence, in order to help clinicians in their decision-making process. Strategies including the choice of antibiotic and dose optimization, antibiotic spectrum narrowing (de-escalation), shortening of duration, shift to oral route or outpatient parenteral antibiotic (including elastomeric pumps), and biomarkers are described and discussed. View Full-Text
Keywords: antimicrobial stewardship; anti-bacterial agents; outpatients; antibiotic optimization; antibiotic policy antimicrobial stewardship; anti-bacterial agents; outpatients; antibiotic optimization; antibiotic policy
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MDPI and ACS Style

Di Bella, S.; Beović, B.; Fabbiani, M.; Valentini, M.; Luzzati, R. Antimicrobial Stewardship: From Bedside to Theory. Thirteen Examples of Old and More Recent Strategies from Everyday Clinical Practice. Antibiotics 2020, 9, 398. https://doi.org/10.3390/antibiotics9070398

AMA Style

Di Bella S, Beović B, Fabbiani M, Valentini M, Luzzati R. Antimicrobial Stewardship: From Bedside to Theory. Thirteen Examples of Old and More Recent Strategies from Everyday Clinical Practice. Antibiotics. 2020; 9(7):398. https://doi.org/10.3390/antibiotics9070398

Chicago/Turabian Style

Di Bella, Stefano, Bojana Beović, Massimiliano Fabbiani, Michael Valentini, and Roberto Luzzati. 2020. "Antimicrobial Stewardship: From Bedside to Theory. Thirteen Examples of Old and More Recent Strategies from Everyday Clinical Practice" Antibiotics 9, no. 7: 398. https://doi.org/10.3390/antibiotics9070398

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