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Article

Oxytetracycline Pharmacokinetics After Intramuscular Administration in Cows with Clinical Metritis Associated with Trueperella Pyogenes Infection

1
Department of Pharmacology, Animal Physiology and Physiological Chemistry, Faculty of Veterinary Medicine, Trakia University, 6000 Stara Zagora, Bulgaria
2
Department of Obstetrics, Reproduction and Reproductive Disorders, Faculty of Veterinary Medicine, Trakia University, 6000 Stara Zagora, Bulgaria
3
Department of Veterinary Microbiology, Infectious and Parasitic Diseases, Faculty of Veterinary Medicine, Trakia University, 6000 Stara Zagora, Bulgaria
*
Author to whom correspondence should be addressed.
Antibiotics 2020, 9(7), 392; https://doi.org/10.3390/antibiotics9070392
Received: 23 June 2020 / Revised: 6 July 2020 / Accepted: 7 July 2020 / Published: 9 July 2020
Systemic therapy with oxytetracycline is often used for treatment of clinical metritis although data about its penetration into the uterus and uterine secretion are lacking. Uterine secretions and milk from six cows with clinical metritis were collected for microbiological assay. The animals were treated intramuscularly with long-acting oxytetracycline (20 mg/kg) and samples of plasma, milk and uterine secretions were collected for determination of the antibiotic concentrations by HPLC-PDA analysis. Pharmacokinetics of the antibiotic and in silico prediction of its penetration into the uterus were described. Trueperella pyogenes with MIC values of 16–64 µg mL−1 was isolated (n of cows = 4) from uterine secretions. Oxytetracycline showed fast absorption and penetration in the uterine secretions and milk. No change of withdrawal time for milk was necessitated in cows with clinical metritis. Maximum levels in uterine secretions and predicted concentrations of oxytetracycline in the uterus were lower than MIC values. Systemic administration of long-acting oxytetracycline did not guarantee clinical cure and was not a suitable choice for treatment of clinical metritis associated with Trueperella pyogenes. The appropriate approach to antibiotic treatment of uterine infections of cows requires knowledge on penetration of the antibiotics at the site of infection and sensitivity of pathogens. View Full-Text
Keywords: oxytetracycline; pharmacokinetics; cows; clinical metritis; Trueperella pyogenes oxytetracycline; pharmacokinetics; cows; clinical metritis; Trueperella pyogenes
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MDPI and ACS Style

Mileva, R.; Karadaev, M.; Fasulkov, I.; Petkova, T.; Rusenova, N.; Vasilev, N.; Milanova, A. Oxytetracycline Pharmacokinetics After Intramuscular Administration in Cows with Clinical Metritis Associated with Trueperella Pyogenes Infection. Antibiotics 2020, 9, 392. https://doi.org/10.3390/antibiotics9070392

AMA Style

Mileva R, Karadaev M, Fasulkov I, Petkova T, Rusenova N, Vasilev N, Milanova A. Oxytetracycline Pharmacokinetics After Intramuscular Administration in Cows with Clinical Metritis Associated with Trueperella Pyogenes Infection. Antibiotics. 2020; 9(7):392. https://doi.org/10.3390/antibiotics9070392

Chicago/Turabian Style

Mileva, Rositsa, Manol Karadaev, Ivan Fasulkov, Tsvetelina Petkova, Nikolina Rusenova, Nasko Vasilev, and Aneliya Milanova. 2020. "Oxytetracycline Pharmacokinetics After Intramuscular Administration in Cows with Clinical Metritis Associated with Trueperella Pyogenes Infection" Antibiotics 9, no. 7: 392. https://doi.org/10.3390/antibiotics9070392

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