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Open AccessArticle

Antimicrobial Spectrum of Titroleane™: A New Potent Anti-Infective Agent

1
SETUBIO SA, Bioparc Vichy, F-03270 Hauterive, France
2
Université de Lorraine, CNRS, L2CM, F-54000 Nancy, France
*
Author to whom correspondence should be addressed.
Antibiotics 2020, 9(7), 391; https://doi.org/10.3390/antibiotics9070391
Received: 13 June 2020 / Revised: 3 July 2020 / Accepted: 5 July 2020 / Published: 8 July 2020
(This article belongs to the Special Issue Antibacterial Activity of Plant Extracts and Essential Oils)
Tea Tree oil (TTO) is well known for its numerous good properties but might be also irritating or toxic when used topically or ingested, thus limiting the number of possible applications in Humans. The aim of the study was to characterize the antimicrobial spectrum as well as the toxicity of Titroleane™, a new anti-infective agent obtained from TTO but cleared of its toxic monoterpenes part. The susceptibility to Titroleane™ of various pathogens (bacteria and fungi) encountered in animal and human health was studied in comparison with that of TTO. Antimicrobial screening was carried out using the broth microdilution method. Activities against aerobic, anaerobic, fastidious and non-fastidious microorganisms were performed. For all microorganisms tested, the MIC values for Titroleane™ ranged from 0.08% to 2.5%, except for Campylobacter jejuni, and Aspergillus niger. In particular, Titroleane™ showed good efficacy against skin and soft tissue infection pathogens, such as methicillin resistant Staphylococcus aureus (MRSA), intra-abdominal infections and oral pathogens, as well as fish farming pathogens. Toxicity testing showed little and similar cytotoxicities between TTO and Titroleane™ of 37% and 23%, respectively at a concentration of 0.025% (v/v). Finally, we demonstrated that the antimicrobial activity of Titroleane™ is similar to that of TTO. View Full-Text
Keywords: Titroleane™; Tea Tree oil; antimicrobial activity; bacteria; fungi Titroleane™; Tea Tree oil; antimicrobial activity; bacteria; fungi
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MDPI and ACS Style

Johansen, B.; Duval, R.E.; Sergere, J.-C. Antimicrobial Spectrum of Titroleane™: A New Potent Anti-Infective Agent. Antibiotics 2020, 9, 391. https://doi.org/10.3390/antibiotics9070391

AMA Style

Johansen B, Duval RE, Sergere J-C. Antimicrobial Spectrum of Titroleane™: A New Potent Anti-Infective Agent. Antibiotics. 2020; 9(7):391. https://doi.org/10.3390/antibiotics9070391

Chicago/Turabian Style

Johansen, Bianca; Duval, Raphaël E.; Sergere, Jean-Christophe. 2020. "Antimicrobial Spectrum of Titroleane™: A New Potent Anti-Infective Agent" Antibiotics 9, no. 7: 391. https://doi.org/10.3390/antibiotics9070391

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Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

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