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Open AccessCommunication

First Report of an Escherichia coli Strain Carrying the Colistin Resistance Determinant mcr-1 from a Dog in South Korea

Bacterial Disease Division, Animal and Plant Quarantine Agency, 177 Hyeksin 8-ro, Gimcheon-si, Gyeongsangbuk-do 39660, Korea
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Author to whom correspondence should be addressed.
Antibiotics 2020, 9(11), 768; https://doi.org/10.3390/antibiotics9110768
Received: 29 September 2020 / Revised: 30 October 2020 / Accepted: 31 October 2020 / Published: 2 November 2020
(This article belongs to the Special Issue Antibiotic Resistance Genes: Spread and Evolution)
We studied the presence of the mobile colistin resistance gene mcr-1 in Escherichia coli isolates recovered from fecal and urine samples of companion animals, that were collected from South Korea in 2018 and 2019. The mcr-1 gene was detected in one colistin-resistant E. coli isolated from a diarrheic dog. The isolate exhibited additional resistance to multiple antimicrobials, including fluoroquinolones and third-generation cephalosporins. The mcr-1 carrying isolate belonged to ST160. The pulsed-field gel electrophoresis pattern of our strain differed from those ST160 E. coli strains previously identified from chickens in Korea. The mcr-1 gene was identified in the IncI2 plasmid. It was also transferred to E. coli J53 recipient strain, with a conjugation efficiency of 2.8 × 10−4. Average nucleotide identity analysis demonstrated that the mcr-1-carrying plasmid in this study was closely related to those from patients in Korea. To the best of our knowledge, this is the first report of mcr-1 carrying E. coli from a companion animal in South Korea. Our findings support One Health approach is necessary to prevent the dissemination of this high-risk gene. View Full-Text
Keywords: colistin; dog; E. coli; mcr-1; One Health; plasmid colistin; dog; E. coli; mcr-1; One Health; plasmid
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MDPI and ACS Style

Moon, D.C.; Mechesso, A.F.; Kang, H.Y.; Kim, S.-J.; Choi, J.-H.; Kim, M.H.; Song, H.-J.; Yoon, S.-S.; Lim, S.-K. First Report of an Escherichia coli Strain Carrying the Colistin Resistance Determinant mcr-1 from a Dog in South Korea. Antibiotics 2020, 9, 768.

AMA Style

Moon DC, Mechesso AF, Kang HY, Kim S-J, Choi J-H, Kim MH, Song H-J, Yoon S-S, Lim S-K. First Report of an Escherichia coli Strain Carrying the Colistin Resistance Determinant mcr-1 from a Dog in South Korea. Antibiotics. 2020; 9(11):768.

Chicago/Turabian Style

Moon, Dong C.; Mechesso, Abraham F.; Kang, Hee Y.; Kim, Su-Jeong; Choi, Ji-Hyun; Kim, Mi H.; Song, Hyun-Ju; Yoon, Soon-Seek; Lim, Suk-Kyung. 2020. "First Report of an Escherichia coli Strain Carrying the Colistin Resistance Determinant mcr-1 from a Dog in South Korea" Antibiotics 9, no. 11: 768.

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