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Antibiotics 2018, 7(2), 39;

Unraveling Nutritional Regulation of Tacrolimus Biosynthesis in Streptomyces tsukubaensis through omic Approaches

Área de Microbiología, Departamento de Biología Molecular, Universidad de León, León 24071, Spain
Instituto de Biotecnología de León, INBIOTEC, Avda. Real no. 1, León 24006, Spain
Departamento de Biología Funcional, Universidad de Oviedo, Oviedo 33006, Spain
Author to whom correspondence should be addressed.
Received: 27 February 2018 / Revised: 23 April 2018 / Accepted: 26 April 2018 / Published: 1 May 2018
(This article belongs to the Special Issue Actinomycetes: The Antibiotics Producers)
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Streptomyces tsukubaensis stands out among actinomycetes by its ability to produce the immunosuppressant tacrolimus. Discovered about 30 years ago, this macrolide is widely used as immunosuppressant in current clinics. Other potential applications for the treatment of cancer and as neuroprotective agent have been proposed in the last years. In this review we introduce the discovery of S. tsukubaensis and tacrolimus, its biosynthetic pathway and gene cluster (fkb) regulation. We have focused this work on the omic studies performed in this species in order to understand tacrolimus production. Transcriptomics, proteomics and metabolomics have improved our knowledge about the fkb transcriptional regulation and have given important clues about nutritional regulation of tacrolimus production that can be applied to improve production yields. Finally, we address some points of S. tsukubaensis biology that deserve more attention. View Full-Text
Keywords: Streptomyces tsukubaensis; tacrolimus; FK506; omics Streptomyces tsukubaensis; tacrolimus; FK506; omics

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Ordóñez-Robles, M.; Santos-Beneit, F.; Martín, J.F. Unraveling Nutritional Regulation of Tacrolimus Biosynthesis in Streptomyces tsukubaensis through omic Approaches. Antibiotics 2018, 7, 39.

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