Next Article in Journal
Identification of Additional Anti-Persister Activity against Borrelia burgdorferi from an FDA Drug Library
Next Article in Special Issue
Focus on the Outer Membrane Factor OprM, the Forgotten Player from Efflux Pumps Assemblies
Previous Article in Journal
Short, Synthetic Cationic Peptides Have Antibacterial Activity against Mycobacterium smegmatis by Forming Pores in Membrane and Synergizing with Antibiotics
Previous Article in Special Issue
The Transcriptional Repressor, MtrR, of the mtrCDE Efflux Pump Operon of Neisseria gonorrhoeae Can Also Serve as an Activator of “off Target” Gene (glnE) Expression
Article Menu

Export Article

Open AccessReview
Antibiotics 2015, 4(3), 379-396;

Multidrug Efflux Systems in Microaerobic and Anaerobic Bacteria

School of Biological Sciences, The University of Hong Kong, Hong Kong Special Administrative Region, Hong Kong, China
Institute of Scientific and Industrial Research, Osaka University, Yamadaoka 1-1, Suita, Osaka 565-0871, Japan
Author to whom correspondence should be addressed.
Academic Editor: Helen I. Zgurskaya
Received: 26 June 2015 / Revised: 11 August 2015 / Accepted: 13 August 2015 / Published: 28 August 2015
(This article belongs to the Special Issue Multi-drug Efflux and Drug Permeation)
Full-Text   |   PDF [697 KB, uploaded 28 August 2015]   |  


Active drug efflux constitutes an important mechanism of antibiotic and multidrug resistance in bacteria. Understanding the distribution, expression, and physiological functions of multidrug efflux pumps, especially under physiologically and clinically relevant conditions of the pathogens, is the key to combat drug resistance. In animal hosts, most wounded, infected and inflamed tissues display low oxygen tensions. In this article, we summarize research development on multidrug efflux pumps in the medicinally relevant microaerobic and anaerobic pathogens and their implications in the effort to combat drug-resistant infections. View Full-Text
Keywords: multi-drug efflux pump; microaerobic bacteria; anaerobic bacteria; efflux pump inhibitors multi-drug efflux pump; microaerobic bacteria; anaerobic bacteria; efflux pump inhibitors

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

Share & Cite This Article

MDPI and ACS Style

Xu, Z.; Yan, A. Multidrug Efflux Systems in Microaerobic and Anaerobic Bacteria. Antibiotics 2015, 4, 379-396.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Antibiotics EISSN 2079-6382 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top