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Antibiotics
Volume 12
Issue 8
10.3390/antibiotics12081269
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Article

Dogs Can Be Reservoirs of Escherichia coli Strains Causing Urinary Tract Infection in Human Household Contacts

by
Peter Damborg
1,
Mattia Pirolo
1,
Laura Schøn Poulsen
1,†,
Niels Frimodt-Møller
2,‡ and
Luca Guardabassi
1,*
1
Department of Veterinary and Animal Sciences, University of Copenhagen, 1870 Frederiksberg, Denmark
2
Department of Clinical Microbiology, Hvidovre Hospital, 2650 Hvidovre, Denmark
*
Author to whom correspondence should be addressed.
†
Current address: Novo Nordisk, 2880 Bagsværd, Denmark.
‡
Current address: Department of Clinical Microbiology, Rigshospitalet, Copenhagen University Hospital, 2100 Copenhagen, Denmark.
Antibiotics 2023, 12(8), 1269; https://doi.org/10.3390/antibiotics12081269
Submission received: 9 June 2023 / Revised: 6 July 2023 / Accepted: 26 July 2023 / Published: 1 August 2023
(This article belongs to the Section Antibiotics in Animal Health)
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Abstract

This study aimed to investigate the role played by pets as reservoirs of Escherichia coli strains causing human urinary tract infections (UTIs) in household contacts. Among 119 patients with community-acquired E. coli UTIs, we recruited 19 patients who lived with a dog or a cat. Fecal swabs from the household pet(s) were screened by antimicrobial selective culture to detect E. coli displaying the resistance profile of the human strain causing UTI. Two dogs shed E. coli isolates indistinguishable from the UTI strain by pulsed-field gel electrophoresis. Ten months later, new feces from these dogs and their owners were screened selectively and quantitatively for the presence of the UTI strain, followed by core-genome phylogenetic analysis of all isolates. In one pair, the resistance phenotype of the UTI strain occurred more frequently in human (108 CFU/g) than in canine feces (104 CFU/g), and human fecal isolates were more similar (2–7 SNPs) to the UTI strain than canine isolates (83–86 SNPs). In the other pair, isolates genetically related to the UTI strain (23–40 SNPs) were only detected in canine feces (105 CFU/g). These results show that dogs can be long-term carriers of E. coli strains causing UTIs in human household contacts.
Keywords: Escherichia coli; transmission; whole-genome sequence; One Health Escherichia coli; transmission; whole-genome sequence; One Health

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MDPI and ACS Style

Damborg, P.; Pirolo, M.; Schøn Poulsen, L.; Frimodt-Møller, N.; Guardabassi, L. Dogs Can Be Reservoirs of Escherichia coli Strains Causing Urinary Tract Infection in Human Household Contacts. Antibiotics 2023, 12, 1269. https://doi.org/10.3390/antibiotics12081269

AMA Style

Damborg P, Pirolo M, Schøn Poulsen L, Frimodt-Møller N, Guardabassi L. Dogs Can Be Reservoirs of Escherichia coli Strains Causing Urinary Tract Infection in Human Household Contacts. Antibiotics. 2023; 12(8):1269. https://doi.org/10.3390/antibiotics12081269

Chicago/Turabian Style

Damborg, Peter, Mattia Pirolo, Laura Schøn Poulsen, Niels Frimodt-Møller, and Luca Guardabassi. 2023. "Dogs Can Be Reservoirs of Escherichia coli Strains Causing Urinary Tract Infection in Human Household Contacts" Antibiotics 12, no. 8: 1269. https://doi.org/10.3390/antibiotics12081269

APA Style

Damborg, P., Pirolo, M., Schøn Poulsen, L., Frimodt-Møller, N., & Guardabassi, L. (2023). Dogs Can Be Reservoirs of Escherichia coli Strains Causing Urinary Tract Infection in Human Household Contacts. Antibiotics, 12(8), 1269. https://doi.org/10.3390/antibiotics12081269

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