Next Article in Journal
Behavioral Components and Context of Antimicrobial Prescription in a Tertiary Hospital in Portugal
Next Article in Special Issue
Insight on Incorporation of Essential Oils as Antimicrobial Substances in Biopolymer-Based Active Packaging
Previous Article in Journal
Methicillin-Resistant Staphylococcus aureus Strains Isolated from Burned Patients in a Tunisian Hospital: Molecular Typing, Virulence Genes, and Antimicrobial Resistance
Previous Article in Special Issue
Artificial Neural Network Prediction of Antiadhesion and Antibiofilm-Forming Effects of Antimicrobial Active Mushroom Extracts on Food-Borne Pathogens
 
 
Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
Journals
Antibiotics
Volume 12
Issue 6
10.3390/antibiotics12061031
antibiotics-logo
Submit to this Journal Review for this Journal Propose a Special Issue
► Article Menu

Article Menu

share Share announcement Help format_quote Cite question_answer Discuss in SciProfiles
first_page
settings
Order Article Reprints
Font Type:
Arial Georgia Verdana
Font Size:
Aa Aa Aa
Line Spacing:
Column Width:
Background:
Article

Towards a Greener Approach for Biomass Valorization: Integration of Supercritical Fluid and Deep Eutectic Solvents

by
Jelena Vladić
1,2,*,
Martina Jakovljević Kovač
3,
Valentina Pavić
4,
Stela Jokić
3,
Siniša Simić
2,
Alexandre Paiva
1,
Igor Jerković
5 and
Ana Rita Duarte
1,*
1
LAQV/REQUIMTE, Faculdade de Ciências e Tecnologia, Universidade Nova de Lisboa, 2829-516 Caparica, Portugal
2
Faculty of Technology, University of Novi Sad, 21000 Novi Sad, Serbia
3
Faculty of Food Technology, Josip Juraj Strossmayer University of Osijek, 31000 Osijek, Croatia
4
Department of Biology, Josip Juraj Strossmayer University Osijek, 31000 Osijek, Croatia
5
Faculty of Chemistry and Technology, University of Split, 21000 Split, Croatia
*
Authors to whom correspondence should be addressed.
Antibiotics 2023, 12(6), 1031; https://doi.org/10.3390/antibiotics12061031
Submission received: 4 May 2023 / Revised: 2 June 2023 / Accepted: 6 June 2023 / Published: 8 June 2023
(This article belongs to the Special Issue Advances in the Discovery of Novel Antimicrobial Agents in Nature and Their Applications)
Browse Figures
Versions Notes

Abstract

A green and sustainable procedure for obtaining Lavandula stoechas extracts with antioxidant and antimicrobial properties was investigated. Green solvents, supercritical CO2, and natural deep eutectic solvents (NADES) together with ultrasound-assisted extraction were used for the sequential extraction of terpene and polyphenols fractions. After the CO2 extraction of the terpene fraction, the residue material was used in an extraction with different NADES (betaine-ethylene glycol (Bet:EG), betaine-glycerol (Bet:Gly), and glycerol-glucose (Gly:Glu)), intensified with an ultrasound-assisted method (at 30 and 60 °C). In the CO2 extract, the major group of components belonged to oxygenated monoterpenes, while the highest polyphenol content with the dominant rutin (438.93 ± 4.60 µg/mL) was determined in Bet:EG extracts (60 °C). Bet:EG extracts also exhibited the most potent antioxidant activity according to DPPH, ABTS, and FRAP assays. Moreover, Bet:EG extracts showed significant inhibitory activity against Gram-positive and Gram-negative bacteria, with minimum inhibitory activity of 0.781–3.125 and 1.563–6.250 mg·mL−1, respectively. By comparing the polyphenolic content and antioxidant and antimicrobial activities of Bet:EG extracts with extracts obtained with conventional solvents (water and ethanol), the superiority of NADES was determined. The established environmentally friendly procedure unifies the requirements of green and sustainable development and modern pharmacognosy because it combines the use of safe alternative solvents, the absence of solvent waste generation, more rational use of resources, and the attainment of safe and quality extracts.
Keywords: Lavandula stoechas; supercritical CO2; deep eutectic solvent; antibacterial activity; antioxidant activity Lavandula stoechas; supercritical CO2; deep eutectic solvent; antibacterial activity; antioxidant activity

Share and Cite

MDPI and ACS Style

Vladić, J.; Jakovljević Kovač, M.; Pavić, V.; Jokić, S.; Simić, S.; Paiva, A.; Jerković, I.; Duarte, A.R. Towards a Greener Approach for Biomass Valorization: Integration of Supercritical Fluid and Deep Eutectic Solvents. Antibiotics 2023, 12, 1031. https://doi.org/10.3390/antibiotics12061031

AMA Style

Vladić J, Jakovljević Kovač M, Pavić V, Jokić S, Simić S, Paiva A, Jerković I, Duarte AR. Towards a Greener Approach for Biomass Valorization: Integration of Supercritical Fluid and Deep Eutectic Solvents. Antibiotics. 2023; 12(6):1031. https://doi.org/10.3390/antibiotics12061031

Chicago/Turabian Style

Vladić, Jelena, Martina Jakovljević Kovač, Valentina Pavić, Stela Jokić, Siniša Simić, Alexandre Paiva, Igor Jerković, and Ana Rita Duarte. 2023. "Towards a Greener Approach for Biomass Valorization: Integration of Supercritical Fluid and Deep Eutectic Solvents" Antibiotics 12, no. 6: 1031. https://doi.org/10.3390/antibiotics12061031

APA Style

Vladić, J., Jakovljević Kovač, M., Pavić, V., Jokić, S., Simić, S., Paiva, A., Jerković, I., & Duarte, A. R. (2023). Towards a Greener Approach for Biomass Valorization: Integration of Supercritical Fluid and Deep Eutectic Solvents. Antibiotics, 12(6), 1031. https://doi.org/10.3390/antibiotics12061031

Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details here.

Article Metrics

Back to TopTop