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Antibiotics
Volume 11
Issue 6
10.3390/antibiotics11060710
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Article

A Retrospective Study on the Effectiveness and Safety of Vancomycin versus Daptomycin in Hemodialysis Patients

by
Hideo Kato
1,2,3,
Mao Hagihara
1,4,
Mariko Kato
1,2,
Yuka Yamagishi
1,
Takumi Umemura
1,
Nobuhiro Asai
1,
Jun Hirai
1,
Takuya Iwamoto
2,3 and
Hiroshige Mikamo
1,*
1
Department of Clinical Infectious Diseases, Aichi Medical University, Nagakute 480-1195, Japan
2
Department of Pharmacy, Mie University Hospital, Tsu 514-8507, Japan
3
Department of Clinical Pharmaceutics, Division of Clinical Medical Science, Mie University Graduate School of Medicine, Tsu 514-8507, Japan
4
Department of Molecular Epidemiology and Biomedical Sciences, Aichi Medical University Hospital, Nagakute 480-1195, Japan
*
Author to whom correspondence should be addressed.
Antibiotics 2022, 11(6), 710; https://doi.org/10.3390/antibiotics11060710
Submission received: 16 April 2022 / Revised: 20 May 2022 / Accepted: 24 May 2022 / Published: 25 May 2022
(This article belongs to the Special Issue Antibiotic Strategy for the Treatment of Infections in Specific Populations)
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Abstract

Vancomycin or daptomycin is administered to hemodialysis patients infected with methicillin-resistant Staphylococcus and Enterococcus species. Although serious concerns regarding nephrotoxicity due to vancomycin have been raised, it might not be a critical issue in hemodialysis patients. Moreover, very few studies have investigated the effectiveness of vancomycin versus daptomycin in patients undergoing hemodialysis. Hence, we retrospectively evaluated the effectiveness and safety of vancomycin and daptomycin in patients undergoing hemodialysis. We investigated the following measures: mortality, clinical and microbiological effectiveness, and incidence of adverse events in hemodialysis patients who received vancomycin or daptomycin from 2014 to 2019. Moreover, we evaluated the covariates related to 30-day mortality. We found that 73 patients received vancomycin, while 34 received daptomycin for the treatment of infections due to methicillin-resistant Staphylococcus aureus, methicillin-resistant coagulase-negative Staphylococci, and Enterococcus faecium. Mortality after vancomycin treatment was significantly lower than daptomycin treatment (4.1% vs. 26.5%, p < 0.01). The clinical and microbiological effectiveness as well as the safety were not significantly different between the two treatments. Although daptomycin treatment with a loading dose was associated with lower mortality, the mortality of the treatment (8.3%) did not differ significantly compared to that of the vancomycin treatment (4.1%). Therefore, our findings suggest that vancomycin remains the first-line treatment for hemodialysis patients; however, a loading dose may be beneficial for patients receiving daptomycin.
Keywords: vancomycin; daptomycin; hemodialysis patient; loading dose vancomycin; daptomycin; hemodialysis patient; loading dose

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MDPI and ACS Style

Kato, H.; Hagihara, M.; Kato, M.; Yamagishi, Y.; Umemura, T.; Asai, N.; Hirai, J.; Iwamoto, T.; Mikamo, H. A Retrospective Study on the Effectiveness and Safety of Vancomycin versus Daptomycin in Hemodialysis Patients. Antibiotics 2022, 11, 710. https://doi.org/10.3390/antibiotics11060710

AMA Style

Kato H, Hagihara M, Kato M, Yamagishi Y, Umemura T, Asai N, Hirai J, Iwamoto T, Mikamo H. A Retrospective Study on the Effectiveness and Safety of Vancomycin versus Daptomycin in Hemodialysis Patients. Antibiotics. 2022; 11(6):710. https://doi.org/10.3390/antibiotics11060710

Chicago/Turabian Style

Kato, Hideo, Mao Hagihara, Mariko Kato, Yuka Yamagishi, Takumi Umemura, Nobuhiro Asai, Jun Hirai, Takuya Iwamoto, and Hiroshige Mikamo. 2022. "A Retrospective Study on the Effectiveness and Safety of Vancomycin versus Daptomycin in Hemodialysis Patients" Antibiotics 11, no. 6: 710. https://doi.org/10.3390/antibiotics11060710

APA Style

Kato, H., Hagihara, M., Kato, M., Yamagishi, Y., Umemura, T., Asai, N., Hirai, J., Iwamoto, T., & Mikamo, H. (2022). A Retrospective Study on the Effectiveness and Safety of Vancomycin versus Daptomycin in Hemodialysis Patients. Antibiotics, 11(6), 710. https://doi.org/10.3390/antibiotics11060710

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