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Volume 11
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10.3390/antibiotics11030298
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Review

Staphyloxanthin as a Potential Novel Target for Deciphering Promising Anti-Staphylococcus aureus Agents

by
Rana A. Elmesseri
1,
Sarra E. Saleh
2,
Heba M. Elsherif
1,
Ibrahim S. Yahia
3,4,5 and
Khaled M. Aboshanab
2,*
1
Department of Microbiology, Faculty of Pharmacy, Misr International University (MIU), Cairo 19648, Egypt
2
Department of Microbiology & Immunology, Faculty of Pharmacy, Ain Shams University (ASU), Cairo 11566, Egypt
3
Laboratory of Nano-Smart Materials for Science and Technology (LNSMST), Department of Physics, Faculty of Science, King Khalid University, P.O. Box 9004, Abha 61441, Saudi Arabia
4
Research Center for Advanced Materials Science (RCAMS), King Khalid University, P.O. Box 9004, Abha 61413, Saudi Arabia
5
Nanoscience Laboratory for Environmental and Biomedical Applications (NLEBA), Semiconductor Laboratory, Department of Physics, Faculty of Education, Ain Shams University, Roxy, Cairo 11757, Egypt
*
Author to whom correspondence should be addressed.
Antibiotics 2022, 11(3), 298; https://doi.org/10.3390/antibiotics11030298
Submission received: 11 January 2022 / Revised: 20 February 2022 / Accepted: 21 February 2022 / Published: 23 February 2022
(This article belongs to the Topic Compounds with Medicinal Value)
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Abstract

Staphylococcus aureus is a fatal Gram-positive pathogen threatening numerous cases of hospital-admitted patients worldwide. The emerging resistance of the pathogen to several antimicrobial agents has pressurized research to propose new strategies for combating antimicrobial resistance. Novel strategies include targeting the virulence factors of S. aureus. One of the most prominent virulence factors of S. aureus is its eponymous antioxidant pigment staphyloxanthin (STX), which is an auspicious target for anti-virulence therapy. This review provides an updated outline on STX and multiple strategies to attenuate this virulence factor. The approaches discussed in this article focus on bioprospective and chemically synthesized inhibitors of STX, inter-species communication and genetic manipulation. Various inhibitor molecules were found to exhibit appreciable inhibitory effect against STX and hence would be able to serve as potential anti-virulence agents for clinical use.
Keywords: anti-virulence; staphyloxanthin; Staphylococcus aureus; CrtM; CrtN; MRSA anti-virulence; staphyloxanthin; Staphylococcus aureus; CrtM; CrtN; MRSA

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MDPI and ACS Style

Elmesseri, R.A.; Saleh, S.E.; Elsherif, H.M.; Yahia, I.S.; Aboshanab, K.M. Staphyloxanthin as a Potential Novel Target for Deciphering Promising Anti-Staphylococcus aureus Agents. Antibiotics 2022, 11, 298. https://doi.org/10.3390/antibiotics11030298

AMA Style

Elmesseri RA, Saleh SE, Elsherif HM, Yahia IS, Aboshanab KM. Staphyloxanthin as a Potential Novel Target for Deciphering Promising Anti-Staphylococcus aureus Agents. Antibiotics. 2022; 11(3):298. https://doi.org/10.3390/antibiotics11030298

Chicago/Turabian Style

Elmesseri, Rana A., Sarra E. Saleh, Heba M. Elsherif, Ibrahim S. Yahia, and Khaled M. Aboshanab. 2022. "Staphyloxanthin as a Potential Novel Target for Deciphering Promising Anti-Staphylococcus aureus Agents" Antibiotics 11, no. 3: 298. https://doi.org/10.3390/antibiotics11030298

APA Style

Elmesseri, R. A., Saleh, S. E., Elsherif, H. M., Yahia, I. S., & Aboshanab, K. M. (2022). Staphyloxanthin as a Potential Novel Target for Deciphering Promising Anti-Staphylococcus aureus Agents. Antibiotics, 11(3), 298. https://doi.org/10.3390/antibiotics11030298

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