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Article

Antimicrobial Activity of Eucalyptus globulus, Azadirachta indica, Glycyrrhiza glabra, Rheum palmatum Extracts and Rhein against Porphyromonas gingivalis

1
Department of Oral and Maxillofacial Surgery, University Medical Center Mainz, Augustusplatz 2, D-55131 Mainz, Germany
2
Department of Chemistry, Johannes Gutenberg-University, Duesbergweg 10–14, D-55128 Mainz, Germany
3
Department of Periodontology and Operative Dentistry, University Medical Center Mainz, Augustusplatz 2, D-55131 Mainz, Germany
4
Department of Medical Microbiology and Hygiene, University of Mainz, Obere Zahlbacherstr. 67, D-55131 Mainz, Germany
*
Author to whom correspondence should be addressed.
Current address: Institute of Virology, University of Mainz, Obere Zahlbacherstr. 67, D-55131 Mainz, Germany.
Academic Editors: Laura Giamperi, Anahi Elena Ada Bucchini and Jean Marc Sabatier
Antibiotics 2022, 11(2), 186; https://doi.org/10.3390/antibiotics11020186
Received: 31 December 2021 / Revised: 20 January 2022 / Accepted: 29 January 2022 / Published: 31 January 2022
(This article belongs to the Special Issue Antimicrobial Activities of Plant Extracts)
Novel plant-derived antimicrobials are of interest in dentistry, especially in the treatment of periodontitis, since the use of established substances is associated with side effects and concerns of antimicrobial resistance have been raised. Thus, the present study was performed to quantify the antimicrobial efficacy of crude plant extracts against Porphyromonas gingivalis, a pathogen associated with periodontitis. The minimal inhibitory concentrations (MICs) of Eucalyptus globulus leaf, Azadirachta indica leaf, Glycyrrhiza glabra root and Rheum palmatum root extracts were determined by broth microdilution for P. gingivalis ATCC 33277 according to CLSI (Clinical and Laboratory Standards Institute). The MICs for the E. globulus, A. indica and G. glabra extracts ranged from 64 mg/L to 1024 mg/L. The lowest MIC was determined for an ethanolic R. palmatum extract with 4 mg/L. The MIC for the anthraquinone rhein was also measured, as the antimicrobial activity of P. palmatum root extracts can be partially traced back to rhein. Rhein showed a remarkably low MIC of 0.125 mg/L. However, the major compounds of the R. palmatum root extract were not further separated and purified. In conclusion, R. palmatum root extracts should be further studied for the treatment of periodontitis. View Full-Text
Keywords: Azadirachta indica; broth microdilution; Glycyrrhiza glabra; plant extracts; Porphyromonas gingivalis; rhein; Rheum palmatum Azadirachta indica; broth microdilution; Glycyrrhiza glabra; plant extracts; Porphyromonas gingivalis; rhein; Rheum palmatum
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MDPI and ACS Style

Müller-Heupt, L.K.; Vierengel, N.; Groß, J.; Opatz, T.; Deschner, J.; von Loewenich, F.D. Antimicrobial Activity of Eucalyptus globulus, Azadirachta indica, Glycyrrhiza glabra, Rheum palmatum Extracts and Rhein against Porphyromonas gingivalis. Antibiotics 2022, 11, 186. https://doi.org/10.3390/antibiotics11020186

AMA Style

Müller-Heupt LK, Vierengel N, Groß J, Opatz T, Deschner J, von Loewenich FD. Antimicrobial Activity of Eucalyptus globulus, Azadirachta indica, Glycyrrhiza glabra, Rheum palmatum Extracts and Rhein against Porphyromonas gingivalis. Antibiotics. 2022; 11(2):186. https://doi.org/10.3390/antibiotics11020186

Chicago/Turabian Style

Müller-Heupt, Lena K., Nina Vierengel, Jonathan Groß, Till Opatz, James Deschner, and Friederike D. von Loewenich. 2022. "Antimicrobial Activity of Eucalyptus globulus, Azadirachta indica, Glycyrrhiza glabra, Rheum palmatum Extracts and Rhein against Porphyromonas gingivalis" Antibiotics 11, no. 2: 186. https://doi.org/10.3390/antibiotics11020186

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