Next Article in Journal
Bee Bread Exhibits Higher Antimicrobial Potential Compared to Bee Pollen
Next Article in Special Issue
Bacteriophage-Delivering Hydrogels: Current Progress in Combating Antibiotic Resistant Bacterial Infection
Previous Article in Journal
Time to Positivity of Blood Cultures Could Inform Decisions on Antibiotics Administration in Neonatal Early-Onset Sepsis

Phage-Encoded Endolysins

Center for Microbiology and Phage Therapy, Biomedical Sciences, Zewail City of Science and Technology, Giza 12578, Egypt
Department of Biomedical Engineering, Sethu Institute of Technology, Tamil Nadu 626115, India
Department of Biomedical Laboratory Science, College of Medicine, University of Ibadan, Ibadan 200284, Nigeria
School of Life Sciences, La Trobe University, Melbourne, VIC 3086, Australia
Center for Biosafety Mega-Science, Key Laboratory of Special Pathogens and Biosafety, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan 430071, China
International College, University of Chinese Academy of Sciences, Beijing 100049, China
Atta ur Rahman School of Applied Biosciences (ASAB), National University of Sciences and Technology (NUST), Islamabad 24090, Pakistan
Bacterial Infections: Antimicrobial Therapies Group, Institute for Bioengineering of Catalonia (IBEC), The Barcelona Institute of Science and Technology (BIST), 08028 Barcelona, Spain
Microbiology Section, Department of Genetics, Microbiology, and Statistics, Faculty of Biology, University of Barcelona, 08028 Barcelona, Spain
Authors to whom correspondence should be addressed.
All authors contributed equally to this work.
Academic Editors: Sidney Hayes and Carl Merril
Antibiotics 2021, 10(2), 124;
Received: 19 December 2020 / Revised: 16 January 2021 / Accepted: 26 January 2021 / Published: 28 January 2021
Due to the global emergence of antibiotic resistance, there has been an increase in research surrounding endolysins as an alternative therapeutic. Endolysins are phage-encoded enzymes, utilized by mature phage virions to hydrolyze the cell wall from within. There is significant evidence that proves the ability of endolysins to degrade the peptidoglycan externally without the assistance of phage. Thus, their incorporation in therapeutic strategies has opened new options for therapeutic application against bacterial infections in the human and veterinary sectors, as well as within the agricultural and biotechnology sectors. While endolysins show promising results within the laboratory, it is important to document their resistance, safety, and immunogenicity for in-vivo application. This review aims to provide new insights into the synergy between endolysins and antibiotics, as well as the formulation of endolysins. Thus, it provides crucial information for clinical trials involving endolysins. View Full-Text
Keywords: endolysin; antibiotic resistance; bacteriophages endolysin; antibiotic resistance; bacteriophages
Show Figures

Figure 1

MDPI and ACS Style

Abdelrahman, F.; Easwaran, M.; Daramola, O.I.; Ragab, S.; Lynch, S.; Oduselu, T.J.; Khan, F.M.; Ayobami, A.; Adnan, F.; Torrents, E.; Sanmukh, S.; El-Shibiny, A. Phage-Encoded Endolysins. Antibiotics 2021, 10, 124.

AMA Style

Abdelrahman F, Easwaran M, Daramola OI, Ragab S, Lynch S, Oduselu TJ, Khan FM, Ayobami A, Adnan F, Torrents E, Sanmukh S, El-Shibiny A. Phage-Encoded Endolysins. Antibiotics. 2021; 10(2):124.

Chicago/Turabian Style

Abdelrahman, Fatma, Maheswaran Easwaran, Oluwasegun I. Daramola, Samar Ragab, Stephanie Lynch, Tolulope J. Oduselu, Fazal Mehmood Khan, Akomolafe Ayobami, Fazal Adnan, Eduard Torrents, Swapnil Sanmukh, and Ayman El-Shibiny. 2021. "Phage-Encoded Endolysins" Antibiotics 10, no. 2: 124.

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

Back to TopTop