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Review

Phage-Encoded Endolysins

1
Center for Microbiology and Phage Therapy, Biomedical Sciences, Zewail City of Science and Technology, Giza 12578, Egypt
2
Department of Biomedical Engineering, Sethu Institute of Technology, Tamil Nadu 626115, India
3
Department of Biomedical Laboratory Science, College of Medicine, University of Ibadan, Ibadan 200284, Nigeria
4
School of Life Sciences, La Trobe University, Melbourne, VIC 3086, Australia
5
Center for Biosafety Mega-Science, Key Laboratory of Special Pathogens and Biosafety, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan 430071, China
6
International College, University of Chinese Academy of Sciences, Beijing 100049, China
7
Atta ur Rahman School of Applied Biosciences (ASAB), National University of Sciences and Technology (NUST), Islamabad 24090, Pakistan
8
Bacterial Infections: Antimicrobial Therapies Group, Institute for Bioengineering of Catalonia (IBEC), The Barcelona Institute of Science and Technology (BIST), 08028 Barcelona, Spain
9
Microbiology Section, Department of Genetics, Microbiology, and Statistics, Faculty of Biology, University of Barcelona, 08028 Barcelona, Spain
*
Authors to whom correspondence should be addressed.
All authors contributed equally to this work.
Academic Editors: Sidney Hayes and Carl Merril
Antibiotics 2021, 10(2), 124; https://doi.org/10.3390/antibiotics10020124
Received: 19 December 2020 / Revised: 16 January 2021 / Accepted: 26 January 2021 / Published: 28 January 2021
Due to the global emergence of antibiotic resistance, there has been an increase in research surrounding endolysins as an alternative therapeutic. Endolysins are phage-encoded enzymes, utilized by mature phage virions to hydrolyze the cell wall from within. There is significant evidence that proves the ability of endolysins to degrade the peptidoglycan externally without the assistance of phage. Thus, their incorporation in therapeutic strategies has opened new options for therapeutic application against bacterial infections in the human and veterinary sectors, as well as within the agricultural and biotechnology sectors. While endolysins show promising results within the laboratory, it is important to document their resistance, safety, and immunogenicity for in-vivo application. This review aims to provide new insights into the synergy between endolysins and antibiotics, as well as the formulation of endolysins. Thus, it provides crucial information for clinical trials involving endolysins. View Full-Text
Keywords: endolysin; antibiotic resistance; bacteriophages endolysin; antibiotic resistance; bacteriophages
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MDPI and ACS Style

Abdelrahman, F.; Easwaran, M.; Daramola, O.I.; Ragab, S.; Lynch, S.; Oduselu, T.J.; Khan, F.M.; Ayobami, A.; Adnan, F.; Torrents, E.; Sanmukh, S.; El-Shibiny, A. Phage-Encoded Endolysins. Antibiotics 2021, 10, 124. https://doi.org/10.3390/antibiotics10020124

AMA Style

Abdelrahman F, Easwaran M, Daramola OI, Ragab S, Lynch S, Oduselu TJ, Khan FM, Ayobami A, Adnan F, Torrents E, Sanmukh S, El-Shibiny A. Phage-Encoded Endolysins. Antibiotics. 2021; 10(2):124. https://doi.org/10.3390/antibiotics10020124

Chicago/Turabian Style

Abdelrahman, Fatma; Easwaran, Maheswaran; Daramola, Oluwasegun I.; Ragab, Samar; Lynch, Stephanie; Oduselu, Tolulope J.; Khan, Fazal M.; Ayobami, Akomolafe; Adnan, Fazal; Torrents, Eduard; Sanmukh, Swapnil; El-Shibiny, Ayman. 2021. "Phage-Encoded Endolysins" Antibiotics 10, no. 2: 124. https://doi.org/10.3390/antibiotics10020124

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