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Review

Bacteriophage-Delivering Hydrogels: Current Progress in Combating Antibiotic Resistant Bacterial Infection

1
Advanced Drug Delivery Group, Faculty of Medicine and Health, School of Pharmacy, The University of Sydney, Sydney, NSW 2006, Australia
2
Phage Consulting, Sydney, NSW 2006, Australia
*
Author to whom correspondence should be addressed.
Academic Editor: Marco Maria D’Andrea
Antibiotics 2021, 10(2), 130; https://doi.org/10.3390/antibiotics10020130
Received: 31 December 2020 / Revised: 22 January 2021 / Accepted: 26 January 2021 / Published: 29 January 2021
Antibiotic resistance remains as an unresolved global challenge in the health care system, posing serious threats to global health. As an alternative to antibiotics, bacteriophage (phage) therapy is rising as a key to combating antibiotic-resistant bacterial infections. In order to deliver a phage to the site of infection, hydrogels have been formulated to incorporate phages, owing to its favorable characteristics in delivering biological molecules. This paper reviews the formulation of phage-delivering hydrogels for orthopedic implant-associated bone infection, catheter-associated urinary tract infection and trauma-associated wound infection, with a focus on the preparation methods, stability, efficacy and safety of hydrogels as phage carriers. View Full-Text
Keywords: bacteriophage (phage); hydrogel; multidrug-resistant bacteria; formulation; efficacy; safety; stability bacteriophage (phage); hydrogel; multidrug-resistant bacteria; formulation; efficacy; safety; stability
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MDPI and ACS Style

Kim, H.Y.; Chang, R.Y.K.; Morales, S.; Chan, H.-K. Bacteriophage-Delivering Hydrogels: Current Progress in Combating Antibiotic Resistant Bacterial Infection. Antibiotics 2021, 10, 130. https://doi.org/10.3390/antibiotics10020130

AMA Style

Kim HY, Chang RYK, Morales S, Chan H-K. Bacteriophage-Delivering Hydrogels: Current Progress in Combating Antibiotic Resistant Bacterial Infection. Antibiotics. 2021; 10(2):130. https://doi.org/10.3390/antibiotics10020130

Chicago/Turabian Style

Kim, Hyun Y., Rachel Y.K. Chang, Sandra Morales, and Hak-Kim Chan. 2021. "Bacteriophage-Delivering Hydrogels: Current Progress in Combating Antibiotic Resistant Bacterial Infection" Antibiotics 10, no. 2: 130. https://doi.org/10.3390/antibiotics10020130

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