Clinical Features and Molecular Characteristics of Methicillin-Susceptible Staphylococcus aureus Ocular Infection in Taiwan
Abstract
:1. Introduction
2. Results
2.1. Clinical Characteristics of MSSA Ocular Infections
2.2. Molecular Typing
2.3. Drug Susceptibility Test
3. Discussion
4. Materials and Methods
4.1. Ethics
4.2. Study Population and Data Collection
4.3. Molecular Characteristics
4.4. Drug Susceptibility Test
4.5. Statistical Analysis
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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CA (n = 46) No. (%) | HA (n = 58) No. (%) | p Value | |
---|---|---|---|
Demographics | |||
Age in years, mean ± SD (range) | 44.6 ± 24.0 (0.1–84) | 52.6 ± 25.0 (0.1–95) | 0.102 |
Sex (male/female) | 22/24 (47.8/52.2) | 25/33 (43.1/56.9) | 0.694 |
Underlying Condition | |||
Diabetes mellitus | 9 (19.6) | 15 (25.9) | 0.491 |
Hypertension | 13 (28.3) | 20 (34.5) | 0.532 |
Pulmonary disease | 3 (6.5) | 6 (10.3) | 0.728 |
Renal disease | 4 (8.7) | 6 (10.3) | 1 |
Liver disease | 2 (4.3) | 5 (8.6) | 0.46 |
Malignancy | 1 (2.2) | 12 (20.7) | 0.006 |
Immunodeficiency | 1 (2.2) | 5 (8.6) | 0.224 |
Current infection a | 0 (0) | 19 (32.9) | <0.001 |
Recent antibiotic use | 1 (2.2) | 15 (25.9) | 0.001 |
Alcoholic | 2 (4.3) | 3 (5.2) | 1 |
Ocular history | |||
Contact lens use | 8 (17.4) | 1 (1.7) | 0.010 |
Ocular surface disease | 11 (23.9) | 23 (39.7) | 0.098 |
Surgery | 9 (19.6) | 37 (63.8) | <0.001 |
Trauma | 8 (17.4) | 9 (15.5) | 0.797 |
CA (n = 46) No. (%) | HA (n = 58) No. (%) | p Value | |
---|---|---|---|
Diagnosis | |||
Lid disorder | 4 (8.7) | 4 (6.9) | 0.730 |
Conjunctivitis | 5 (10.9) | 23 (39.7) | 0.001 |
Keratitis | 29 (63.0) | 17 (29.3) | <0.001 |
Endophthalmitis | 3 (6.5) | 2 (3.4) | 0.653 |
Wound infection) | 1 (2.2) | 5 (8.6) | 0.224 |
Lacrimal system disorder | 4 (8.7) | 4 (6.9) | 0.730 |
Others (%) | 0 (0) | 3 (5.2) | 0.253 |
Treatment | |||
Surgical intervention | 5 (10.9) | 11 (19) | 0.288 |
Inpatient | 14 (30.4) | 33 (56.9) | 0.009 |
Outpatient/ED | 32 (69.6) | 25 (43.1) | 0.010 |
Pulsotypes | BA | F | AX | BW | D | Others |
---|---|---|---|---|---|---|
No. isolates (n = 104) | 35 (33.7%) | 20 (19.2%) | 8 (7.7%) | 8 (7.7%) | 7 (6.7%) | 26 (25%) |
CA (n = 46) | 13 (28.3%) | 10 (21.7%) | 4 (8.7%) | 3 (6.5%) | 5 (10.9%) | 11 (23.9%) |
HA (n = 58) | 22 (37.9%) | 10 (17.2%) | 4 (6.9%) | 5 (8.6%) | 2 (3.4%) | 15 (25.9%) |
p-value | 0.404 | 0.621 | 0.730 | 1 | 0.237 | 1 |
PVL-positive (n = 7) | 0 | 0 | 1 | 1 | 2 | 3 |
Sequence type | 1 (1/7), 7 (4/7), 6427 (1/7), 6457 (1/7) | 15 (6/6) | 188 (2/3), 6426 a (1/3) | Untypeable a (4/4) | 59 a (2/4), 97 (1/3), 338 a (1/4) | 1232 aa (3), 59, 1281, 72, 30 (2), 96, 398, 508, 509, 573, 672 a, 6453, untypeable |
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Chen, Y.-L.; Kang, E.Y.-C.; Yeh, L.-K.; Ma, D.H.K.; Tan, H.-Y.; Chen, H.-C.; Hung, K.-H.; Huang, Y.-C.; Hsiao, C.-H. Clinical Features and Molecular Characteristics of Methicillin-Susceptible Staphylococcus aureus Ocular Infection in Taiwan. Antibiotics 2021, 10, 1445. https://doi.org/10.3390/antibiotics10121445
Chen Y-L, Kang EY-C, Yeh L-K, Ma DHK, Tan H-Y, Chen H-C, Hung K-H, Huang Y-C, Hsiao C-H. Clinical Features and Molecular Characteristics of Methicillin-Susceptible Staphylococcus aureus Ocular Infection in Taiwan. Antibiotics. 2021; 10(12):1445. https://doi.org/10.3390/antibiotics10121445
Chicago/Turabian StyleChen, Yueh-Ling, Eugene Yu-Chuan Kang, Lung-Kun Yeh, David H. K. Ma, Hsin-Yuan Tan, Hung-Chi Chen, Kuo-Hsuan Hung, Yhu-Chering Huang, and Ching-Hsi Hsiao. 2021. "Clinical Features and Molecular Characteristics of Methicillin-Susceptible Staphylococcus aureus Ocular Infection in Taiwan" Antibiotics 10, no. 12: 1445. https://doi.org/10.3390/antibiotics10121445