Biosensors 2019, 9(1), 4; https://doi.org/10.3390/bios9010004
ZIF Nanocrystal-Based Surface Acoustic Wave (SAW) Electronic Nose to Detect Diabetes in Human Breath
Fabio A. Bahos 1, Arianee Sainz-Vidal 1, Celia Sánchez-Pérez 1
, José M. Saniger 1, Isabel Gràcia 2, María M. Saniger-Alba 3 and Daniel Matatagui 1,4,*
, José M. Saniger 1, Isabel Gràcia 2, María M. Saniger-Alba 3 and Daniel Matatagui 1,4,*
1
Instituto de Ciencias Aplicadas y Tecnología (ICAT), Universidad Nacional Autónoma de México, Ciudad Universitaria, Ciudad de México 04510, Mexico
2
Instituto de Microelectrónica de Barcelona (IMB), CSIC, Campus UAB, 08193 Bellaterra, Spain
3
Instituto Nacional de la Nutrición Salvador Zubiran, Department of Neurophysiology, Tlalpan 14080, Mexico
4
SENSAVAN, Instituto de Tecnologías Físicas y de la Información (ITEFI), CSIC, Serrano 144, 28006 Madrid, Spain
*
Author to whom correspondence should be addressed.
Received: 7 November 2018 / Revised: 14 December 2018 / Accepted: 21 December 2018 / Published: 26 December 2018
(This article belongs to the Special Issue Electronic Noses for Biomedical Applications and Environmental Monitoring)
Abstract
In the present work, a novel, portable and innovative eNose composed of a surface acoustic wave (SAW) sensor array based on zeolitic imidazolate frameworks, ZIF-8 and ZIF-67 nanocrystals (pure and combined with gold nanoparticles), as sensitive layers has been tested as a non-invasive system to detect different disease markers, such as acetone, ethanol and ammonia, related to the diagnosis and control of diabetes mellitus through exhaled breath. The sensors have been prepared by spin coating, achieving continuous sensitive layers at the surface of the SAW device. Low concentrations (5 ppm, 10 ppm and 25 ppm) of the marker analytes were measured, obtaining high sensitivities, good reproducibility, short time response and fast signal recovery. View Full-TextKeywords:
eNose; gas sensor; SAW; surface acoustic wave; Love wave; diabetes; breath; VOC; ZIF; Zeolite
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Bahos, F.A.; Sainz-Vidal, A.; Sánchez-Pérez, C.; Saniger, J.M.; Gràcia, I.; Saniger-Alba, M.M.; Matatagui, D. ZIF Nanocrystal-Based Surface Acoustic Wave (SAW) Electronic Nose to Detect Diabetes in Human Breath. Biosensors 2019, 9, 4.
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