Next Article in Journal
Electrochemical Biosensors as Potential Diagnostic Devices for Autoimmune Diseases
Previous Article in Journal
Solid-State rGO-PEDOT:PSS Transducing Material for Cost-Effective Enzymatic Sensing
Previous Article in Special Issue
Surface Enhanced Raman Spectroscopy of Lactoferrin Adsorbed on Silvered Porous Silicon Covered with Graphene
Open AccessArticle

Waveguiding and SERS Simplified Raman Spectroscopy on Biological Samples

Department of Experimental and Clinical Medicine, University “Magna Graecia” of Catanzaro, 88100 Catanzaro, Italy
Structural Molecular Imaging Light Enhanced Spectroscopies Laboratory, Physical Science and Engineering Division, King Abdullah University of Science and Technology, Thuwal 23955-6900, Saudi Arabia
Author to whom correspondence should be addressed.
Biosensors 2019, 9(1), 37;
Received: 21 December 2018 / Revised: 19 February 2019 / Accepted: 21 February 2019 / Published: 3 March 2019
(This article belongs to the Special Issue Applications of Raman Techniques in Biosensing)
Biomarkers detection at an ultra-low concentration in biofluids (blood, serum, saliva, etc.) is a key point for the early diagnosis success and the development of personalized therapies. However, it remains a challenge due to limiting factors like (i) the complexity of analyzed media, and (ii) the aspecificity detection and the poor sensitivity of the conventional methods. In addition, several applications require the integration of the primary sensors with other devices (microfluidic devices, capillaries, flasks, vials, etc.) where transducing the signal might be difficult, reducing performances and applicability. In the present work, we demonstrate a new class of optical biosensor we have developed integrating an optical waveguide (OWG) with specific plasmonic surfaces. Exploiting the plasmonic resonance, the devices give consistent results in surface enhanced Raman spectroscopy (SERS) for continuous and label-free detection of biological compounds. The OWG allows driving optical signals in the proximity of SERS surfaces (detection area) overcoming spatial constraints, in order to reach places previously optically inaccessible. A rutile prism couples the remote laser source to the OWG, while a Raman spectrometer collects the SERS far field scattering. The present biosensors were implemented by a simple fabrication process, which includes photolithography and nanofabrication. By using such devices, it was possible to detect cell metabolites like Phenylalanine (Phe), Adenosine 5-triphosphate sodium hydrate (ATP), Sodium Lactate, Human Interleukin 6 (IL6), and relate them to possible metabolic pathway variation. View Full-Text
Keywords: prism coupling; optical waveguide; optical biosensors; Raman micro-spectroscopy prism coupling; optical waveguide; optical biosensors; Raman micro-spectroscopy
Show Figures

Figure 1

MDPI and ACS Style

Valpapuram, I.; Candeloro, P.; Coluccio, M.L.; Parrotta, E.I.; Giugni, A.; Das, G.; Cuda, G.; Di Fabrizio, E.; Perozziello, G. Waveguiding and SERS Simplified Raman Spectroscopy on Biological Samples. Biosensors 2019, 9, 37.

AMA Style

Valpapuram I, Candeloro P, Coluccio ML, Parrotta EI, Giugni A, Das G, Cuda G, Di Fabrizio E, Perozziello G. Waveguiding and SERS Simplified Raman Spectroscopy on Biological Samples. Biosensors. 2019; 9(1):37.

Chicago/Turabian Style

Valpapuram, Immanuel; Candeloro, Patrizio; Coluccio, Maria L.; Parrotta, Elvira I.; Giugni, Andrea; Das, Gobind; Cuda, Gianni; Di Fabrizio, Enzo; Perozziello, Gerardo. 2019. "Waveguiding and SERS Simplified Raman Spectroscopy on Biological Samples" Biosensors 9, no. 1: 37.

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

Search more from Scilit
Back to TopTop