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The Recent Advances in Raman Microscopy and Imaging Techniques for Biosensors

Thermo Fisher Scientific, 2 Radcliff Rd., Tewksbury, MA 01876, USA
Biosensors 2019, 9(1), 25;
Received: 7 January 2019 / Revised: 30 January 2019 / Accepted: 6 February 2019 / Published: 12 February 2019
(This article belongs to the Special Issue Applications of Raman Techniques in Biosensing)
PDF [4116 KB, uploaded 27 February 2019]


Raman microspectroscopy is now well established as one of the most powerful analytical techniques for a diverse range of applications in physical (material) and biological sciences. Consequently, the technique provides exceptional analytical opportunities to the science and technology of biosensing due to its capability to analyze both parts of a biosensor system—biologically sensitive components, and a variety of materials and systems used in physicochemical transducers. Recent technological developments in Raman spectral imaging have brought additional possibilities in two- and three-dimensional (2D and 3D) characterization of the biosensor’s constituents and their changes on a submicrometer scale in a label-free, real-time nondestructive method of detection. In this report, the essential components and features of a modern confocal Raman microscope are reviewed using the instance of Thermo Scientific DXRxi Raman imaging microscope, and examples of the potential applications of Raman microscopy and imaging for constituents of biosensors are presented. View Full-Text
Keywords: Raman; spectroscopy; microscopy; imaging; biological cells; SWCNT Raman; spectroscopy; microscopy; imaging; biological cells; SWCNT

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Rzhevskii, A. The Recent Advances in Raman Microscopy and Imaging Techniques for Biosensors. Biosensors 2019, 9, 25.

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