Next Article in Journal
A Novel Wearable Device for Continuous Ambulatory ECG Recording: Proof of Concept and Assessment of Signal Quality
Next Article in Special Issue
Response Surface Methodology for the Optimisation of Electrochemical Biosensors for Heavy Metals Detection
Previous Article in Journal
Suppressing Non-Specific Binding of Proteins onto Electrode Surfaces in the Development of Electrochemical Immunosensors
Previous Article in Special Issue
Metal Oxide Nanoparticle Based Electrochemical Sensor for Total Antioxidant Capacity (TAC) Detection in Wine Samples
Open AccessArticle

Ultrathin Functional Polymer Modified Graphene for Enhanced Enzymatic Electrochemical Sensing

1
Systems and Process Engineering Centre (SPEC), Centre for NanoHealth, College of Engineering, Swansea University, Swansea SA2 8PP, UK
2
Key Laboratory of Optoelectronic Technology & Systems (Chongqing University), Ministry of Education, Chongqing 400044, China
3
Centre for Intelligent Sensing Technology, College of Optoelectronic Engineering, Chongqing University, Chongqing 400044, China
4
Department of Chemistry, College of Science, Swansea University, Swansea SA2 8PP, UK
*
Authors to whom correspondence should be addressed.
Biosensors 2019, 9(1), 16; https://doi.org/10.3390/bios9010016
Received: 10 December 2018 / Revised: 11 January 2019 / Accepted: 15 January 2019 / Published: 18 January 2019
(This article belongs to the Special Issue Enzymatic Electrochemical Biosensors)
Grafting thin polymer layers on graphene enables coupling target biomolecules to graphene surfaces, especially through amide and aldehyde linkages with carboxylic acid and primary amine derivatives, respectively. However, functionalizing monolayer graphene with thin polymer layers without affecting their exceptional electrical properties remains challenging. Herein, we demonstrate the controlled modification of chemical vapor deposition (CVD) grown single layer graphene with ultrathin polymer 1,5-diaminonaphthalene (DAN) layers using the electropolymerization technique. It is observed that the controlled electropolymerization of DAN monomer offers continuous polymer layers with thickness ranging between 5–25 nm. The surface characteristics of pure and polymer modified graphene was examined. As anticipated, the number of surface amine groups increases with increases in the layer thickness. The effects of polymer thickness on the electron transfer rates were studied in detail and a simple route for the estimation of surface coverage of amine groups was demonstrated using the electrochemical analysis. The implications of grafting ultrathin polymer layers on graphene towards horseradish peroxidase (HRP) enzyme immobilization and enzymatic electrochemical sensing of H2O2 were discussed elaborately. View Full-Text
Keywords: graphene; enzyme immobilization; functional polymers; electropolymerization; bio electrochemistry; electrochemical sensing; glucose biosensor; biofunctionalization graphene; enzyme immobilization; functional polymers; electropolymerization; bio electrochemistry; electrochemical sensing; glucose biosensor; biofunctionalization
Show Figures

Graphical abstract

MDPI and ACS Style

Devadoss, A.; Forsyth, R.; Bigham, R.; Abbasi, H.; Ali, M.; Tehrani, Z.; Liu, Y.; Guy, O.J. Ultrathin Functional Polymer Modified Graphene for Enhanced Enzymatic Electrochemical Sensing. Biosensors 2019, 9, 16.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Search more from Scilit
 
Search
Back to TopTop