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Biosensors 2018, 8(4), 104; https://doi.org/10.3390/bios8040104

Applications of Nanomaterials for Immunosensing

Centre for BioNano Interactions, School of Chemistry, University College Dublin, D04 V1W8 Dublin, Ireland
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Received: 25 September 2018 / Revised: 24 October 2018 / Accepted: 29 October 2018 / Published: 1 November 2018
(This article belongs to the Special Issue Functional Nanomaterials for Biosensing and Bioimaging)
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Abstract

In biomedical science among several other growing fields, the detection of specific biological agents or biomolecular markers, from biological samples is crucial for early diagnosis and decision-making in terms of appropriate treatment, influencing survival rates. In this regard, immunosensors are based on specific antibody-antigen interactions, forming a stable immune complex. The antigen-specific detection antibodies (i.e., biomolecular recognition element) are generally immobilized on the nanomaterial surfaces and their interaction with the biomolecular markers or antigens produces a physico-chemical response that modulates the signal readout. Lowering the detection limits for particular biomolecules is one of the key parameters when designing immunosensors. Thus, their design by combining the specificity and versatility of antibodies with the intrinsic properties of nanomaterials offers a plethora of opportunities for clinical diagnosis. In this review, we show a comprehensive set of recent developments in the field of nanoimmunosensors and how they are progressing the detection and validation for a wide range of different biomarkers in multiple diseases and what are some drawbacks and considerations of the uses of such devices and their expansion. View Full-Text
Keywords: nanomaterials; immunosensors; biomarkers; antigen; antibody; immune complex; cancer; therapeutics; diagnostics nanomaterials; immunosensors; biomarkers; antigen; antibody; immune complex; cancer; therapeutics; diagnostics
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Lara, S.; Perez-Potti, A. Applications of Nanomaterials for Immunosensing. Biosensors 2018, 8, 104.

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