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Erratum published on 22 June 2018, see Biosensors 2018, 8(3), 58.
Open AccessFeature PaperArticle

A Low-Cost Inkjet-Printed Aptamer-Based Electrochemical Biosensor for the Selective Detection of Lysozyme

1
Department of Electrical and Computer Engineering, University of New Hampshire, Durham, NH 03824, USA
2
Department of Chemical Engineering, University of New Hampshire, Durham, NH 03824, USA
3
Center for Advanced Materials and Manufacturing Innovation, University of New Hampshire, Durham, NH 03824, USA
*
Author to whom correspondence should be addressed.
Biosensors 2018, 8(1), 7; https://doi.org/10.3390/bios8010007
Received: 30 November 2017 / Revised: 23 December 2017 / Accepted: 10 January 2018 / Published: 15 January 2018
Recently, inkjet-printing has gained increased popularity in applications such as flexible electronics and disposable sensors, as well as in wearable sensors because of its multifarious advantages. This work presents a novel, low-cost immobilization technique using inkjet-printing for the development of an aptamer-based biosensor for the detection of lysozyme, an important biomarker in various disease diagnosis. The strong affinity between the carbon nanotube (CNT) and the single-stranded DNA is exploited to immobilize the aptamers onto the working electrode by printing the ink containing the dispersion of CNT-aptamer complex. The inkjet-printing method enables aptamer density control, as well as high resolution patternability. Our developed sensor shows a detection limit of 90 ng/mL with high target selectivity against other proteins. The sensor also demonstrates a shelf-life for a reasonable period. This technology has potential for applications in developing low-cost point-of-care diagnostic testing kits for home healthcare. View Full-Text
Keywords: biosensor; aptamer; lysozyme; electrochemical impedance spectroscopy; inkjet printing; point-of-care biosensor; aptamer; lysozyme; electrochemical impedance spectroscopy; inkjet printing; point-of-care
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MDPI and ACS Style

Khan, N.I.; Maddaus, A.G.; Song, E. A Low-Cost Inkjet-Printed Aptamer-Based Electrochemical Biosensor for the Selective Detection of Lysozyme. Biosensors 2018, 8, 7. https://doi.org/10.3390/bios8010007

AMA Style

Khan NI, Maddaus AG, Song E. A Low-Cost Inkjet-Printed Aptamer-Based Electrochemical Biosensor for the Selective Detection of Lysozyme. Biosensors. 2018; 8(1):7. https://doi.org/10.3390/bios8010007

Chicago/Turabian Style

Khan, Niazul I.; Maddaus, Alec G.; Song, Edward. 2018. "A Low-Cost Inkjet-Printed Aptamer-Based Electrochemical Biosensor for the Selective Detection of Lysozyme" Biosensors 8, no. 1: 7. https://doi.org/10.3390/bios8010007

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