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Biosensors 2016, 6(1), 1;

Asymmetric Mach–Zehnder Interferometer Based Biosensors for Aflatoxin M1 Detection

Nanoscience Laboratory, Department of Physics, University of Trento, Via Sommarive 14, 38123 Povo (TN), Italy
LaBSSAH, Fondazione Bruno Kessler, Via Sommarive 18, 38123 Povo, Italy
LioniX B.V., Enschede 7522, The Netherlands
These authors contributed equally to this work.
Author to whom correspondence should be addressed.
Academic Editor: Yuliya Semenova
Received: 30 October 2015 / Revised: 22 December 2015 / Accepted: 30 December 2015 / Published: 6 January 2016
(This article belongs to the Special Issue Optical Sensors for Biomedical Applications)
Full-Text   |   PDF [2310 KB, uploaded 6 January 2016]   |  


In this work, we present a study of Aflatoxin M1 detection by photonic biosensors based on Si3N4 Asymmetric Mach–Zehnder Interferometer (aMZI) functionalized with antibodies fragments (Fab′). We measured a best volumetric sensitivity of 104 rad/RIU, leading to a Limit of Detection below 5 × 10−7 RIU. On sensors functionalized with Fab′, we performed specific and non-specific sensing measurements at various toxin concentrations. Reproducibility of the measurements and re-usability of the sensor were also investigated. View Full-Text
Keywords: Mach–Zehnder interferometer; biosensor; Aflatoxin M1; limit of detection; Fab′ Mach–Zehnder interferometer; biosensor; Aflatoxin M1; limit of detection; Fab′

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Chalyan, T.; Guider, R.; Pasquardini, L.; Zanetti, M.; Falke, F.; Schreuder, E.; Heideman, R.G.; Pederzolli, C.; Pavesi, L. Asymmetric Mach–Zehnder Interferometer Based Biosensors for Aflatoxin M1 Detection. Biosensors 2016, 6, 1.

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