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Development of Functional Fluorescent Molecular Probes for the Detection of Biological Substances

Health Research Institute, National Institute of Advanced Industrial Science and Technology (AIST), Central 6, 1-1-1 Higashi, Tsukuba 305-8566, Japan
School of Bioscience and Biotechnology, Tokyo University of Technology, 1404-1 Katakura, Hachioji, Tokyo 192-0982, Japan
Author to whom correspondence should be addressed.
Academic Editor: A. Sheila Holmes-Smith
Biosensors 2015, 5(2), 337-363;
Received: 22 April 2015 / Revised: 8 June 2015 / Accepted: 9 June 2015 / Published: 18 June 2015
(This article belongs to the Special Issue Fluorescence Based Sensing Technologies)
This review is confined to sensors that use fluorescence to transmit biochemical information. Fluorescence is, by far, the most frequently exploited phenomenon for chemical sensors and biosensors. Parameters that define the application of such sensors include intensity, decay time, anisotropy, quenching efficiency, and luminescence energy transfer. To achieve selective (bio)molecular recognition based on these fluorescence phenomena, various fluorescent elements such as small organic molecules, enzymes, antibodies, and oligonucleotides have been designed and synthesized over the past decades. This review describes the immense variety of fluorescent probes that have been designed for the recognitions of ions, small and large molecules, and their biological applications in terms of intracellular fluorescent imaging techniques. View Full-Text
Keywords: molecular probes; sensors; metal ions; proteins; DNA molecular probes; sensors; metal ions; proteins; DNA
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Suzuki, Y.; Yokoyama, K. Development of Functional Fluorescent Molecular Probes for the Detection of Biological Substances. Biosensors 2015, 5, 337-363.

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