Next Article in Journal
A Novel and Sensitive Fluorescent Probe for Glyphosate Detection Based on Cu2+ Modulated Polydihydroxyphenylalanine Nanoparticles
Next Article in Special Issue
Unique Electron-Transfer-Mediated Electrochemiluminescence of AuPt Bimetallic Nanoclusters and the Application in Cancer Immunoassay
Previous Article in Journal
Catalytic Modification of Porous Two-Dimensional Ni-MOFs on Portable Electrochemical Paper-Based Sensors for Glucose and Hydrogen Peroxide Detection
Previous Article in Special Issue
Behind the Optimization of the Sensor Film: Bioconjugation of Triangular Gold Nanoparticles with Hemoproteins for Sensitivity Enhancement of Enzymatic Biosensors
 
 
Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
Journals
Biosensors
Volume 13
Issue 5
10.3390/bios13050509
biosensors-logo
Submit to this Journal Review for this Journal Propose a Special Issue
► Article Menu

Article Menu

share Share announcement Help format_quote Cite question_answer Discuss in SciProfiles
first_page
settings
Order Article Reprints
Font Type:
Arial Georgia Verdana
Font Size:
Aa Aa Aa
Line Spacing:
Column Width:
Background:
Article

Development of Levo-Lansoprazole Chiral Molecularly Imprinted Polymer Sensor Based on the Polylysine–Phenylalanine Complex Framework Conformational Separation

by
Lianming Zhang
1,*,
Zian Wang
1,
Dan Li
1,
Yali Yuan
1,*,
Huixiang Ouyang
2,* and
Jianping Li
1
1
College of Chemistry and Bioengineering, Guilin University of Technology, Guilin 541004, China
2
College of Chemistry & Environment Engineering, Baise University, Baise 533000, China
*
Authors to whom correspondence should be addressed.
Biosensors 2023, 13(5), 509; https://doi.org/10.3390/bios13050509
Submission received: 21 February 2023 / Revised: 20 April 2023 / Accepted: 25 April 2023 / Published: 28 April 2023
(This article belongs to the Special Issue Nanomaterial-Based Electrochemical Biosensors and Its Application in Miniaturized Analysis)
Browse Figures
Versions Notes

Abstract

The efficacies and toxicities of chiral drug enantiomers are often dissimilar, necessitating chiral recognition methods. Herein, a polylysine–phenylalanine complex framework was used to prepare molecularly imprinted polymers (MIPs) as sensors with enhanced specific recognition capabilities for levo-lansoprazole. The properties of the MIP sensor were investigated using Fourier-transform infrared spectroscopy and electrochemical methods. The optimal sensor performance was achieved by applying self-assembly times of 30.0 and 25.0 min for the complex framework and levo-lansoprazole, respectively, eight electropolymerization cycles with o-phenylenediamine as the functional monomer, an elution time of 5.0 min using an ethanol/acetic acid/H2O mixture (2/3/8, V/V/V) as the eluent, and a rebound time of 10.0 min. A linear relationship was observed between the sensor response intensity (ΔI) and logarithm of the levo-lansoprazole concentration (l-g C) in the range of 1.0 × 10−13–3.0 × 10−11 mol/L. Compared with a conventional MIP sensor, the proposed sensor showed more efficient enantiomeric recognition, with high selectivity and specificity for levo-lansoprazole. The sensor was successfully applied to levo-lansoprazole detection in enteric-coated lansoprazole tablets, thus demonstrating its suitability for practical applications.
Keywords: molecularly imprinted; complex framework; selectivity; enantiomer; levo-lansoprazole molecularly imprinted; complex framework; selectivity; enantiomer; levo-lansoprazole

Share and Cite

MDPI and ACS Style

Zhang, L.; Wang, Z.; Li, D.; Yuan, Y.; Ouyang, H.; Li, J. Development of Levo-Lansoprazole Chiral Molecularly Imprinted Polymer Sensor Based on the Polylysine–Phenylalanine Complex Framework Conformational Separation. Biosensors 2023, 13, 509. https://doi.org/10.3390/bios13050509

AMA Style

Zhang L, Wang Z, Li D, Yuan Y, Ouyang H, Li J. Development of Levo-Lansoprazole Chiral Molecularly Imprinted Polymer Sensor Based on the Polylysine–Phenylalanine Complex Framework Conformational Separation. Biosensors. 2023; 13(5):509. https://doi.org/10.3390/bios13050509

Chicago/Turabian Style

Zhang, Lianming, Zian Wang, Dan Li, Yali Yuan, Huixiang Ouyang, and Jianping Li. 2023. "Development of Levo-Lansoprazole Chiral Molecularly Imprinted Polymer Sensor Based on the Polylysine–Phenylalanine Complex Framework Conformational Separation" Biosensors 13, no. 5: 509. https://doi.org/10.3390/bios13050509

APA Style

Zhang, L., Wang, Z., Li, D., Yuan, Y., Ouyang, H., & Li, J. (2023). Development of Levo-Lansoprazole Chiral Molecularly Imprinted Polymer Sensor Based on the Polylysine–Phenylalanine Complex Framework Conformational Separation. Biosensors, 13(5), 509. https://doi.org/10.3390/bios13050509

Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details here.

Article Metrics

Back to TopTop