Fiber-Enhanced Stimulated Raman Scattering and Sensitive Detection of Dilute Solutions

Guo, Li; Huang, Jing; Chen, Yaxin; Zhang, Bohan; Ji, Minbiao

doi:10.3390/bios12040243

Open AccessArticle

Fiber-Enhanced Stimulated Raman Scattering and Sensitive Detection of Dilute Solutions

by

Li Guo

¹,

Jing Huang

¹

,

Yaxin Chen

¹,

Bohan Zhang

¹ and

Minbiao Ji

^1,2,*

¹

State Key Laboratory of Surface Physics and Department of Physics, Human Phenome Institute, Academy for Engineering and Technology, Key Laboratory of Micro and Nano Photonic Structures (Ministry of Education), Fudan University, Shanghai 200433, China

²

Yiwu Research Institute, Fudan University, Chengbei Road, Yiwu 322000, China

^*

Author to whom correspondence should be addressed.

Biosensors 2022, 12(4), 243; https://doi.org/10.3390/bios12040243

Submission received: 21 March 2022 / Revised: 8 April 2022 / Accepted: 12 April 2022 / Published: 14 April 2022

(This article belongs to the Special Issue Optical Sensors for Bio-Sensing, Imaging and Theranostics Applications)

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Abstract

Stimulated Raman scattering (SRS) is known to gain coherent amplification of molecular vibrations that allow for rapid and label-free chemical imaging in the microscopy setting. However, the tightly focused laser spot has limited the detection sensitivity, partly due to the tiny interaction volume. Here, we report the use of metal-lined hollow-core fiber (MLHCF) to improve the sensitivity of SRS in sensing dilute solutions by extending the light–matter interaction volume through the fiber waveguide. With a focusing lens (100 mm FL) and 320 μm diameter fiber, we demonstrated an optimum enhancement factor of ~20 at a fiber length of 8.3 cm. More importantly, the MLHCF exhibited a significantly suppressed cross-phase modulation (XPM) background, enabling the detection of ~0.7 mM DMSO in water. Furthermore, the relationship between fiber length and SRS signal could be well explained theoretically. The fiber-enhanced SRS (FE-SRS) method may be further optimized and bears potential in the sensitive detection of molecules in the solution and gas phases.

Keywords: stimulated Raman scattering; fiber enhanced; spectroscopy; biosensing

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MDPI and ACS Style

Guo, L.; Huang, J.; Chen, Y.; Zhang, B.; Ji, M. Fiber-Enhanced Stimulated Raman Scattering and Sensitive Detection of Dilute Solutions. Biosensors 2022, 12, 243. https://doi.org/10.3390/bios12040243

AMA Style

Guo L, Huang J, Chen Y, Zhang B, Ji M. Fiber-Enhanced Stimulated Raman Scattering and Sensitive Detection of Dilute Solutions. Biosensors. 2022; 12(4):243. https://doi.org/10.3390/bios12040243

Chicago/Turabian Style

Guo, Li, Jing Huang, Yaxin Chen, Bohan Zhang, and Minbiao Ji. 2022. "Fiber-Enhanced Stimulated Raman Scattering and Sensitive Detection of Dilute Solutions" Biosensors 12, no. 4: 243. https://doi.org/10.3390/bios12040243

APA Style

Guo, L., Huang, J., Chen, Y., Zhang, B., & Ji, M. (2022). Fiber-Enhanced Stimulated Raman Scattering and Sensitive Detection of Dilute Solutions. Biosensors, 12(4), 243. https://doi.org/10.3390/bios12040243

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Fiber-Enhanced Stimulated Raman Scattering and Sensitive Detection of Dilute Solutions

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